Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study

被引:16
作者
Maasen, Kim [1 ]
Eussen, Simone J. P. M. [2 ]
Dagnelie, Pieter C. [2 ]
Houben, Alfons J. H. M. [1 ]
Webers, Carroll A. B. [3 ]
Schram, Miranda T. [4 ]
Berendschot, Tos T. J. M. [3 ]
Stehouwer, Coen D. A.
Opperhuizen, Antoon [5 ,6 ]
van Greevenbroek, Marleen M. J. [1 ]
Schalkwijk, Casper G. [1 ]
机构
[1] Maastricht Univ Med Ctr, CARIM Sch Cardiovasc Dis, Dept Internal Med, Maastricht, Netherlands
[2] Maastricht Univ Med Ctr, CAPHRI Care & Publ Hlth Res Inst, CARIM Sch Cardiovasc Dis, Dept Epidemiol, Maastricht, Netherlands
[3] Univ Eye Clin Maastricht, Maastricht Univ Med Ctr, Maastricht, Netherlands
[4] Maastricht Univ Med Ctr, Heart & Vasc Ctr, Departmentof Internal Med, Maastricht, Netherlands
[5] Maastricht Univ Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Dept Pharmacol & Toxicol, Maastricht, Netherlands
[6] Netherlands Food & Consumer Prod Safety Author, Off Risk Assessment & Res, Utrecht, Netherlands
基金
欧盟地平线“2020”;
关键词
diet; dicarbonyls; oxoaldehyde; methylglyoxal; glyoxal; 3-deoxyglucosone; observational cohort; advanced glycation endproducts; inflammation; microcirculation; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; THERMAL HYPEREMIA; DICARBONYL STRESS; HYPERGLYCEMIA; IMPAIRMENT; GLYOXALASE; FOOD;
D O I
10.1093/ajcn/nqac195
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background Dicarbonyls are major reactive precursors of advanced glycation endproducts (AGEs). Dicarbonyls are formed endogenously and also during food processing. Circulating dicarbonyls and AGEs are associated with inflammation and microvascular complications of diabetes, but for dicarbonyls from the diet these associations are currently unknown. Objectives We sought to examine the associations of dietary dicarbonyl intake with low-grade inflammation and microvascular function. Methods In 2792 participants (mean +/- SD age: 60 +/- 8 y; 50% men; 26% type 2 diabetes) of the population-based cohort the Maastricht Study, we estimated the habitual intake of the dicarbonyls methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) by linking FFQ outcome data to our food composition database of the MGO, GO, and 3-DG content of >200 foods. Low-grade inflammation was assessed as six plasma biomarkers, which were compiled in a z score. Microvascular function was assessed as four plasma biomarkers, compiled in a zscore; as diameters and flicker light-induced dilation in retinal microvessels; as heat-induced skin hyperemic response; and as urinary albumin excretion. Cross-sectional associations of dietary dicarbonyls with low-grade inflammation and microvascular function were investigated using linear regression with adjustments for age, sex, potential confounders related to cardiometabolic risk factors, and lifestyle and dietary factors. Results Fully adjusted analyses revealed that higher intake of MGO was associated with a lower z score for inflammation [standardized beta coefficient (STD beta): -0.05; 95% CI: -0.09 to -0.01, with strongest inverse associations for hsCRP and TNF-alpha: both -0.05; -0.10 to -0.01]. In contrast, higher dietary MGO intake was associated with impaired retinal venular dilation after full adjustment (STD beta: -0.07; 95% CI: -0.12 to -0.01), but not with the other features of microvascular function. GO and 3-DG intakes were not consistently associated with any of the outcomes. Conclusion Higher habitual intake of MGO was associated with less low-grade inflammation. This novel, presumably beneficial, association is the first observation of an association between MGO intake and health outcomes in humans and warrants further investigation.
引用
收藏
页码:1715 / 1728
页数:14
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