Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3

被引：59
作者：
Nicolaou, KC
Frederick, MO
Petrovic, G
Cole, KP
Loizidou, EZ
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 16期
关键词：
azaspiracids; fused-ring systems; natural products; spiro compounds; total synthesis;
D O I：
10.1002/anie.200600295
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The 39 steps: The recently proposed revised structures of azaspiracid-2 and -3 (see picture), the two most potent members of the azaspiracid family, have been confirmed through the total syntheses of the two compounds. These 39-step syntheses represent a major improvement over the first-generation synthesis of azaspiracid-1 (50 steps). (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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页码：2609 / 2615
页数：7
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