Selective Chromofluorogenic Sensing of Heparin by using Functionalised Silica Nanoparticles Containing Binding Sites and a Signalling Reporter

被引：41

作者：

Climent, Estela ^{[1
]}

Calero, Pilar ^{[1
]}

Marcos, M. Dolores ^{[1
]}

Martinez-Manez, Ramon ^{[1
]}

Sancenon, Felix ^{[1
]}

Soto, Juan ^{[1
]}

机构：

[1] Univ Politecn Valencia, Inst Quim Mol Aplicada, Valencia 46022, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2009年 / 15卷 / 08期

关键词：

chromogenic sensors; heparin; hybrid materials; ion channels; molecular recognition; SELF-ASSEMBLED MONOLAYERS; HYBRID MATERIALS; RECOGNITION; SQUARAINES; SENSOR; CHEMOSENSORS; BLOOD; HG2+; PHOSPHATE; PROTAMINE;

D O I：

10.1002/chem.200802074

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Heparin detective: Silica nanoparticles functionalised with ion-channel scaffolds were prepared and used for the chromofluorogenic sensing of heparin in aqueous environments (see figure). The surface of the nanoparticles was functionalised with polyamines (binding sites) and thiols. The reaction of a dye (squaraine) with the surface thiol groups was selectively inhibited by the coordination of heparin with the partly protonated polyamines.

引用

页码：1816 / 1820

页数：5

共 69 条

[1]

Ajayaghosh A, 2002, ANGEW CHEM INT EDIT, V41, P1766, DOI 10.1002/1521-3773(20020517)41:10<1766::AID-ANIE1766>3.0.CO

[2]

2-4

[3]

Ajayaghosh A., 2002, ANGEW CHEM, V114, P1844

[4] Self-assembly of tripodal squaraines: Cation-assisted expression of molecular chirality and change from spherical to helical morphology [J].

Ajayaghosh, Ayyappanpillai ;

Chithra, Parayalil ;

Varghese, Reji .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (1-2) :230-233

[5] What anions do to N-H-containing receptors [J].

Amendola, Valeria ;

Esteban-Gomez, David ;

Fabbrizzi, Luigi ;

Licchelli, Maurizio .

ACCOUNTS OF CHEMICAL RESEARCH, 2006, 39 (05) :343-353

[6] Some guidelines for the design of anion receptors [J].

Amendola, Valeria ;

Bonizzoni, Marco ;

Esteban-Gomez, David ;

Fabbrizzi, Luigi ;

Licchelli, Maurizio ;

Sancenon, Felix ;

Taglietti, Angelo .

COORDINATION CHEMISTRY REVIEWS, 2006, 250 (11-12) :1451-1470

[7]

[Anonymous], 2007, ANGEW CHEM

[8] Voltammetric detection of inorganic phosphate using ion-channel sensing with self-assembled monolayers of a hydrogen bond-forming receptor [J].

Aoki, H ;

Hasegawa, K ;

Tohda, K ;

Umezawa, Y .

BIOSENSORS & BIOELECTRONICS, 2003, 18 (2-3) :261-267

[9] A controlled supramolecular approach toward cation-specific chemosensors: Alkaline earth metal ion-driven exciton signaling in squaraine tethered podands [J].

Arunkumar, E ;

Chithra, P ;

Ajayaghosh, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (21) :6590-6598

[10] Self-assembled monolayers of bis-thioctic ester derivatives of oligoethyleneglycols:: remarkable selectivity for K+/Na+ recognition [J].

Bandyopadhyay, K ;

Liu, HY ;

Liu, SG ;

Echegoyen, L .

CHEMICAL COMMUNICATIONS, 2000, (02) :141-142

← 1 2 3 4 5 6 7 →