Genetic aspects of intervertebral disc degeneration

被引：52
作者：
Hanaei, Sara [2 ,3 ]
Abdollahzade, Sina [5 ]
Khoshnevisan, Alireza [5 ]
Kepler, Christopher K. [6 ]
Rezaei, Nima [1 ,2 ,3 ,4 ]
机构：
[1] Univ Tehran Med Sci, Childrens Med Ctr, Res Ctr Immunodeficiencies, Tehran 14194, Iran
[2] Univ Tehran Med Sci, Sch Med, Mol Immunol Res Ctr, Tehran 14194, Iran
[3] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran 14194, Iran
[4] Univ Sci Educ & Res Network, Tehran 1494, Iran
[5] Univ Tehran Med Sci, Shariati Hosp, Dept Neurosurg, Tehran 14194, Iran
[6] Thomas Jefferson Univ Hosp, Dept Orthopaed Surg, Rothman Inst, Philadelphia, PA 19107 USA
来源：
REVIEWS IN THE NEUROSCIENCES | 2015年 / 26卷 / 05期
关键词：
collagen; genetics; intervertebral disc degeneration; VITAMIN-D-RECEPTOR; HUMAN-NUCLEUS-PULPOSUS; SURGICAL-TREATMENT; RISK-FACTOR; DISEASE; POLYMORPHISM; ASSOCIATION; EXPRESSION; ALLELE; CARTILAGE;
D O I：
10.1515/revneuro-2014-0077
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could play a significant role in the etiology of this disease. Besides, the interactions with environmental factors could make the role of genetic factors more complicated. Genetic variations in disc components could participate in developing degenerative disc disease through altering the normal homeostasis of discs. Gene polymorphisms in disc proteins (collagens I, II, III, IX, and XI), proteoglycans (aggrecan), cytokines (interleukins I, VI, and X), enzymes (matrix metalloproteinases II, III, and IX), and vitamin D receptor seem to play considerable roles in the pathology of this disease. There are also many other investigated genes that could somehow take part in the process. However, it seems that more studies are needed to clarify the exact role of genetics in IVDD.
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收藏
页码：581 / 606
页数：26
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