Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects

被引：757

作者：

Cai, WB

Shin, DW

Chen, K

Gheysens, O

Cao, QZ

Wang, SX

Gambhir, SS

Chen, XY

机构：

[1] Stanford Univ, Sch Med, MIPS, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Bio X Program, Dept Radiol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Bioengn, Sch Med, Stanford, CA 94305 USA

来源：

NANO LETTERS | 2006年 / 6卷 / 04期

关键词：

D O I：

10.1021/nl052405t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered OD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.

引用

页码：669 / 676

页数：8

共 42 条

[1] Nanocrystal targeting in vivo [J].