The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

被引：86
作者：
Ariston Gabriel, Abakundana Nsenga [1 ,2 ]
Wang, Fang [3 ]
Jiao, Qinlian [1 ,4 ]
Yvette, Umwali [2 ,5 ]
Yang, Xuemei [1 ]
Al-Ameri, Samed Ahmed [1 ,2 ]
Du, Lutao [1 ]
Wang, Yun-shan [1 ]
Wang, Chuanxin [1 ]
机构：
[1] Shandong Univ, Second Hosp, Dept Clin Lab, Cheeloo Coll Med, Jinan 250033, Shandong, Peoples R China
[2] Shandong Univ, Sch Med, Dept Clin Lab Diagnost, Cheeloo Coll Med, Jinan 250012, Shandong, Peoples R China
[3] Shandong Univ, Inst Med Sci, Second Hosp, Cheeloo Coll Med, Jinan 250033, Shandong, Peoples R China
[4] Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
[5] Shandong Univ, Qilu Hosp, Dept Clin Lab, Cheeloo Coll Med, Jinan 250012, Shandong, Peoples R China
来源：
MOLECULAR CANCER | 2020年 / 19卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Exosomes; Pancreatic cancer; Biomarker; Treatment; METASTASIS; RISK;
D O I：
10.1186/s12943-020-01245-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominent mediator of intercellular communication, and they regulate, instruct, and re-educate their surrounding microenvironment and target specific organs. Due to accumulative evidence proved that exosomes are involved in metastasis, cell proliferation, EMT, angiogenesis, and TME of pancreatic cancer, exosomes are crucial potential candidates to detect pancreatic cancer early. This review aims to convey the current understanding of the main functions employed by exosomes in early diagnosis and treatment of pancreatic cancer.
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页数：9
相关论文
共 95 条
[31]   Tumor exosomal microRNAs thwarting anti-tumor immune responses in nasopharyngeal carcinomas [J].
Kapetanakis, Nikiforos-Ioannis ;
Baloche, Valentin ;
Busson, Pierre .
ANNALS OF TRANSLATIONAL MEDICINE, 2017, 5 (07)
[32]  
Kaur S, 2012, BIOMARK MED, V6, P597, DOI [10.2217/BMM.12.69, 10.2217/bmm.12.69]
[33]  
Kawamura S, 2019, J HEPATOBILIARY PANC
[34]   ExoCarta: A Web-Based Compendium of Exosomal Cargo [J].
Keerthikumar, Shivakumar ;
Chisanga, David ;
Ariyaratne, Dinuka ;
Al Saffar, Haidar ;
Anand, Sushma ;
Zhao, Kening ;
Samuel, Monisha ;
Pathan, Mohashin ;
Jois, Markandeya ;
Chilamkurti, Naveen ;
Gangoda, Lahiru ;
Mathivanan, Suresh .
JOURNAL OF MOLECULAR BIOLOGY, 2016, 428 (04) :688-692
[35]  
Kim H, 2019, PROTEOME SCI
[36]  
Kimura H, 2019, CLIN CANC RES
[37]  
Ko J, 2017, ACS NANO
[38]  
Kondo N, 2017, 2017 56TH ANNUAL CONFERENCE OF THE SOCIETY OF INSTRUMENT AND CONTROL ENGINEERS OF JAPAN (SICE), P100, DOI 10.23919/SICE.2017.8105630
[39]  
Korc M, 2018, PANCREAT CANC CANC E
[40]   Decoding the Secret of Cancer by Means of Extracellular Vesicles [J].
Kosaka, Nobuyoshi .
JOURNAL OF CLINICAL MEDICINE, 2016, 5 (02)
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