Gut microbiota modulate the immune effect against hepatitis B virus infection

被引：30

作者：

Xu, D. ^{[1
]}

Huang, Y. ^{[1
]}

Wang, J. ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Infect Dis, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Crit Care Med, Wuhan 430030, Peoples R China

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2015年 / 34卷 / 11期

关键词：

CHRONIC VIRAL-HEPATITIS; MEDIATED LIVER-INJURY; TOLL-LIKE RECEPTORS; INTESTINAL MICROBIOTA; PERSISTENT INFECTION; INNATE IMMUNITY; HBV INFECTION; T-CELLS; RESPONSES; SYSTEM;

D O I：

10.1007/s10096-015-2464-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The immunological mechanisms by which hepatitis B virus (HBV) initiates and maintains acute or chronic infection, even the formation of cirrhosis and hepatocellular carcinoma, are still undefined. An increasing number of studies have shown that intestinal flora regulate immune homeostasis, and, thus, protect the immunologic function against hepatitis virus infection. In this article, we discuss gut microbiota and its potential immune effects against HBV infection. It may provide a novel insight into the pathogenesis of HBV infection, as well as a potential therapeutic target to HBV-related disease.

引用

页码：2139 / 2147

页数：9

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