Influence of Genetically Modified Human Umbilical Cord Blood Mononuclear Cells on the Expression of Schwann Cell Molecular Determinants in Spinal Cord Injury

被引：7
作者：
Galieva, L. R. [1 ]
Mukhamedshina, Y. O. [1 ,2 ]
Akhmetzyanova, E. R. [1 ]
Gilazieva, Z. E. [1 ]
Arkhipova, S. S. [1 ]
Garanina, E. E. [1 ]
Rizvanov, A. A. [1 ]
机构：
[1] Kazan Fed Univ, Kazan, Russia
[2] Kazan State Med Univ, Kazan, Russia
来源：
STEM CELLS INTERNATIONAL | 2018年 / 2018卷
关键词：
NERVE GROWTH-FACTOR; REPAIR; PROTEIN; TRANSPLANTATION; REGENERATION; PERIPHERIN; MIGRATION; RECOVERY; TISSUE;
D O I：
10.1155/2018/4695275
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Spinal cord injury (SCI) unavoidably results in death of not only neurons but also glial cells. In particular, the death of oligodendrocytes leads to impaired nerve impulse conduction in intact axons. However, after SCI, the Schwann cells (SCs) are capable of migrating towards an area of injury and participating in the formation of functional myelin. In addition to SCI, cell-based therapy can influence the migration of SCs and the expression of their molecular determinants. In a number of cases, it can be explained by the ability of implanted cells to secrete neurotrophic factors (NTFs). Genetically modified stem and progenitor cells overexpressing NTFs have recently attracted special attention of researchers and are most promising for the purposes of regenerative medicine. Therefore, we have studied the effect of genetically modified human umbilical cord blood mononuclear cells on the expression of SC molecular determinants in SCI.
引用
收藏
页数：11
相关论文
共 43 条
[1]   NERVE GROWTH-FACTOR AND ITS LOW-AFFINITY RECEPTOR PROMOTE SCHWANN-CELL MIGRATION [J].
ANTON, ES ;
WESKAMP, G ;
REICHARDT, LF ;
MATTHEW, WD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) :2795-2799
[2]   A Rare Myelin Protein Zero (MPZ) Variant Alters Enhancer Activity In Vitro and In Vivo [J].
Antonellis, Anthony ;
Dennis, Megan Y. ;
Burzynski, Grzegorz ;
Huynh, Jimmy ;
Maduro, Valerie ;
Hodonsky, Chani J. ;
Khajavi, Mehrdad ;
Szigeti, Kinga ;
Mukkamala, Sandeep ;
Bessling, Seneca L. ;
Pavan, William J. ;
McCallion, Andrew S. ;
Lupski, James R. ;
Green, Eric D. .
PLOS ONE, 2010, 5 (12)
[3]   Efficient myelin repair in the macaque spinal cord by autologous grafts of Schwann cells [J].
Bachelin, C ;
Lachapelle, F ;
Girard, C ;
Moissonnier, P ;
Serguera-Lagache, C ;
Mallet, J ;
Fontaine, D ;
Chojnowski, A ;
Le Guern, E ;
Nait-Oumesmar, B ;
Baron-Van Evercooren, A .
BRAIN, 2005, 128 :540-549
[4]   Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury [J].
Bartus, Katalin ;
Galino, Jorge ;
James, Nicholas D. ;
Hernandez-Miranda, Luis R. ;
Dawes, John M. ;
Fricker, Florence R. ;
Garratt, Alistair N. ;
McMahon, Stephen B. ;
Ramer, Matt S. ;
Birchmeier, Carmen ;
Bennett, David L. H. ;
Bradbury, Elizabeth J. .
BRAIN, 2016, 139 :1394-1416
[5]   Transient growth factor delivery sustains regenerated axons after spinal cord injury [J].
Blesch, Armin ;
Tuszynski, Mark H. .
JOURNAL OF NEUROSCIENCE, 2007, 27 (39) :10535-10545
[6]   CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA [J].
Bracci-Laudiero, L ;
Celestino, D ;
Starace, G ;
Antonelli, A ;
Lambiase, A ;
Procoli, A ;
Rumi, C ;
Lai, M ;
Picardi, A ;
Ballatore, G ;
Bonini, S ;
Aloe, L .
JOURNAL OF NEUROIMMUNOLOGY, 2003, 136 (1-2) :130-139
[7]   The transcription factor Sox10 is a key regulator of peripheral glial development [J].
Britsch, S ;
Goerich, DE ;
Riethmacher, D ;
Peirano, RI ;
Rossner, M ;
Nave, KA ;
Birchmeier, C ;
Wegner, M .
GENES & DEVELOPMENT, 2001, 15 (01) :66-78
[8]   Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells [J].
Cao, QL ;
Xu, XM ;
DeVries, WH ;
Enzmann, GU ;
Ping, PP ;
Tsoulfas, P ;
Wood, PM ;
Bunge, MB ;
Whittemore, SR .
JOURNAL OF NEUROSCIENCE, 2005, 25 (30) :6947-6957
[9]  
Chen Chun-Ta, 2008, Pediatrics and Neonatology, V49, P77, DOI 10.1016/S1875-9572(08)60017-0
[10]   Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons [J].
Clarke, W. Thomas ;
Edwards, Ben ;
McCullagh, Karl J. A. ;
Kemp, Matthew W. ;
Moorwood, Catherine ;
Sherman, Diane L. ;
Burgess, Matthew ;
Davies, Kay E. .
JOURNAL OF CELL SCIENCE, 2010, 123 (15) :2543-2552
12345