Four new biflavonoids from Selaginella uncinata and their anti-anoxic effect

被引：45

作者：

Zheng, Jun-Xia ^{[1
]}

Wang, Nai-Li ^{[2
]}

Liu, Hong-Wei ^{[3
]}

Chen, Hai-Feng ^{[4
]}

Li, Ming-Ming ^{[5
]}

Wu, Li-Ying ^{[5
]}

Fan, Ming ^{[5
]}

Yao, Xin-Sheng ^{[1
,6
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Medica, Shenyang, Peoples R China

[2] Tsinghua Univ, Res Inst, Key Lab Res & Dev New Drugs, Shenzhen 518057, Peoples R China

[3] Capital Univ Med Sci, Sch Chem Biol & Pharmaceut Sci, Beijing, Peoples R China

[4] Xiamen Univ, Inst Biomed Res, Xiamen, Peoples R China

[5] Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100730, Peoples R China

[6] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 10期

关键词：

Selaginella uncinata (Desv; ) Spring; biflavonoids; anti-anoxic effect; uncinatabiflavones A-D;

D O I：

10.1080/10286020802181166

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The 60% ethanolic extract of Selaginella uncinata (Desv.) Spring possessed potent anti-anoxic effect in the anoxic PC12 cell assay. A phytochemical study of its EtOAc-soluble part led to the isolation of four new and three known biflavonoids. Their structures were established on the basis of physico-chemical properties and spectroscopic analysis. The absolute configurations of the new compounds were determined with the aid of circular dichroism (CD) spectroscopy. Compounds 4 and 5 showed potent anti-anoxic effect in the anoxic PC12 cell assay.

引用

页码：945 / 952

页数：8

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