A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials Evaluating the Evidence Base of Melatonin, Light Exposure, Exercise, and Complementary and Alternative Medicine for Patients with Insomnia Disorder
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Baglioni, Chiara
[1
,2
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Bostanova, Zarina
[1
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Bacaro, Valeria
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Guglielmo Marconi Univ, Dept Human Sci, I-00193 Rome, ItalyUniv Freiburg, Dept Psychiat & Psychotherapy, Med Ctr, Fac Med, D-79104 Freiburg, Germany
Bacaro, Valeria
[2
]
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Benz, Fee
[1
]
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Hertenstein, Elisabeth
[3
]
Spiegelhalder, Kai
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Univ Freiburg, Dept Psychiat & Psychotherapy, Med Ctr, Fac Med, D-79104 Freiburg, GermanyUniv Freiburg, Dept Psychiat & Psychotherapy, Med Ctr, Fac Med, D-79104 Freiburg, Germany
Spiegelhalder, Kai
[1
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Ruecker, Gerta
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Univ Freiburg, Inst Med Biometry & Stat, Med Ctr, Fac Med, D-79104 Freiburg, GermanyUniv Freiburg, Dept Psychiat & Psychotherapy, Med Ctr, Fac Med, D-79104 Freiburg, Germany
Ruecker, Gerta
[4
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Frase, Lukas
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Univ Freiburg, Dept Psychiat & Psychotherapy, Med Ctr, Fac Med, D-79104 Freiburg, GermanyUniv Freiburg, Dept Psychiat & Psychotherapy, Med Ctr, Fac Med, D-79104 Freiburg, Germany
Frase, Lukas
[1
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Riemann, Dieter
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Univ Freiburg, Dept Psychiat & Psychotherapy, Med Ctr, Fac Med, D-79104 Freiburg, GermanyUniv Freiburg, Dept Psychiat & Psychotherapy, Med Ctr, Fac Med, D-79104 Freiburg, Germany
Riemann, Dieter
[1
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Feige, Bernd
[1
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[1] Univ Freiburg, Dept Psychiat & Psychotherapy, Med Ctr, Fac Med, D-79104 Freiburg, Germany
[2] Guglielmo Marconi Univ, Dept Human Sci, I-00193 Rome, Italy
Insomnia is a prevalent disorder and it leads to relevant impairment in health-related quality of life. Recent clinical guidelines pointed out that Cognitive-Behavior Therapy for Insomnia (CBT-I) should be considered as first-line intervention. Nevertheless, many other interventions are commonly used by patients or have been proposed as effective for insomnia. These include melatonin, light exposure, exercise, and complementary and alternative medicine. Evaluation of comparable effectiveness of these interventions with first-line intervention for insomnia is however still lacking. We conducted a systematic review and network meta-analysis on the effects of these interventions. PubMed, PsycInfo, PsycArticles, MEDLINE, and CINAHL were systematically searched and 40 studies were included in the systematic review, while 36 were entered into the meta-analysis. Eight network meta-analyses were conducted. Findings support effectiveness of melatonin in improving sleep-onset difficulties and of meditative movement therapies for self-report sleep efficiency and severity of the insomnia disorder. Some support was observed for exercise, hypnotherapy, and transcranial magnetic resonance, but the number of studies for these interventions is still too small. None of the considered interventions received superior evidence to CBT-I, which should be more widely disseminated in primary care.
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Univ Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
Univ Utrecht, Utrecht Inst Pharmaceut Sci UIPS, Fac Sci, Dept Pharmacoepidemiol & Pharmacotherapy, NL-3584 CM Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
van Geijlswijk, Ingeborg M.
van der Heijden, Kristiaan B.
论文数: 0引用数: 0
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Leiden Univ, Fac Social Sci, Dept Clin Child & Adolescent Studies, Leiden, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
van der Heijden, Kristiaan B.
Egberts, A. C. G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utrecht, Utrecht Inst Pharmaceut Sci UIPS, Fac Sci, Dept Pharmacoepidemiol & Pharmacotherapy, NL-3584 CM Utrecht, Netherlands
Univ Med Ctr Utrecht, Div Lab & Pharm, Dept Clin Pharm, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
Egberts, A. C. G.
Korzilius, Hubert P. L. M.
论文数: 0引用数: 0
h-index: 0
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Radboud Univ Nijmegen, Inst Management Res, NL-6525 ED Nijmegen, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
Korzilius, Hubert P. L. M.
Smits, Marcel G.
论文数: 0引用数: 0
h-index: 0
机构:
Gelderse Vallei Hosp Ede, Dept Sleep Wake Disorders & Chronobiol, Ede, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
机构:
Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Yeung, Wing-Fai
Ho, Fiona Yan-Yee
论文数: 0引用数: 0
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机构:
Educ Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China
Educ Univ Hong Kong, Ctr Psychosocial Hlth, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Ho, Fiona Yan-Yee
Chung, Ka-Fai
论文数: 0引用数: 0
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Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Chung, Ka-Fai
Zhang, Zhang-Jin
论文数: 0引用数: 0
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Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Zhang, Zhang-Jin
Yu, Branda Yee-Man
论文数: 0引用数: 0
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Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Yu, Branda Yee-Man
Suen, Lorna Kwai-Ping
论文数: 0引用数: 0
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Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Suen, Lorna Kwai-Ping
Chan, Lily Ying-Tung
论文数: 0引用数: 0
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机构:
Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Chan, Lily Ying-Tung
Chen, Hai-Yong
论文数: 0引用数: 0
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Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Chen, Hai-Yong
Ho, Lai-Ming
论文数: 0引用数: 0
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Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Ho, Lai-Ming
Lao, Li-Xing
论文数: 0引用数: 0
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Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
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Chinese Univ Hong Kong, Shatin Hosp, Dept Psychiat, Sleep Assessment Unit, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Shatin Hosp, Dept Psychiat, Sleep Assessment Unit, Shatin, Hong Kong, Peoples R China
Zhang, Bin
Wing, Yun-Kwok
论文数: 0引用数: 0
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机构:
Chinese Univ Hong Kong, Shatin Hosp, Dept Psychiat, Sleep Assessment Unit, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Shatin Hosp, Dept Psychiat, Sleep Assessment Unit, Shatin, Hong Kong, Peoples R China
机构:
Univ Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
Univ Utrecht, Utrecht Inst Pharmaceut Sci UIPS, Fac Sci, Dept Pharmacoepidemiol & Pharmacotherapy, NL-3584 CM Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
van Geijlswijk, Ingeborg M.
van der Heijden, Kristiaan B.
论文数: 0引用数: 0
h-index: 0
机构:
Leiden Univ, Fac Social Sci, Dept Clin Child & Adolescent Studies, Leiden, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
van der Heijden, Kristiaan B.
Egberts, A. C. G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utrecht, Utrecht Inst Pharmaceut Sci UIPS, Fac Sci, Dept Pharmacoepidemiol & Pharmacotherapy, NL-3584 CM Utrecht, Netherlands
Univ Med Ctr Utrecht, Div Lab & Pharm, Dept Clin Pharm, Utrecht, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
Egberts, A. C. G.
Korzilius, Hubert P. L. M.
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Inst Management Res, NL-6525 ED Nijmegen, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
Korzilius, Hubert P. L. M.
Smits, Marcel G.
论文数: 0引用数: 0
h-index: 0
机构:
Gelderse Vallei Hosp Ede, Dept Sleep Wake Disorders & Chronobiol, Ede, NetherlandsUniv Utrecht, Fac Vet Med, Dept Pharm, NL-3584 CM Utrecht, Netherlands
机构:
Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Yeung, Wing-Fai
Ho, Fiona Yan-Yee
论文数: 0引用数: 0
h-index: 0
机构:
Educ Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China
Educ Univ Hong Kong, Ctr Psychosocial Hlth, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Ho, Fiona Yan-Yee
Chung, Ka-Fai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Chung, Ka-Fai
Zhang, Zhang-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Zhang, Zhang-Jin
Yu, Branda Yee-Man
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Yu, Branda Yee-Man
Suen, Lorna Kwai-Ping
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Suen, Lorna Kwai-Ping
Chan, Lily Ying-Tung
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Chan, Lily Ying-Tung
Chen, Hai-Yong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Chen, Hai-Yong
Ho, Lai-Ming
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
Ho, Lai-Ming
Lao, Li-Xing
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China
机构:
Chinese Univ Hong Kong, Shatin Hosp, Dept Psychiat, Sleep Assessment Unit, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Shatin Hosp, Dept Psychiat, Sleep Assessment Unit, Shatin, Hong Kong, Peoples R China
Zhang, Bin
Wing, Yun-Kwok
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Shatin Hosp, Dept Psychiat, Sleep Assessment Unit, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Shatin Hosp, Dept Psychiat, Sleep Assessment Unit, Shatin, Hong Kong, Peoples R China