Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

被引：41

作者：

Barreiro, Carlos ^{[2
]}

Prieto, Carlos ^{[2
]}

Sola-Landa, Alberto ^{[2
]}

Solera, Elena ^{[2
]}

Martinez-Castro, Miriam ^{[1
]}

Perez-Redondo, Rosario ^{[2
]}

Garcia-Estrada, Carlos ^{[2
]}

Aparicio, Jesus F. ^{[1
,2
]}

Fernandez-Martinez, Lorena T. ^{[2
]}

Santos-Aberturas, Javier ^{[1
]}

Salehi-Najafabadi, Zahra ^{[1
]}

Rodriguez-Garcia, Antonio ^{[1
,2
]}

Tauch, Andreas ^{[3
]}

Martin, Juan F. ^{[1
]}

机构：

[1] Univ Leon, Dept Mol Biol, Area Microbiol, E-24071 Leon, Spain

[2] INBIOTEC Inst Biotecnol Lean, Leon, Spain

[3] Univ Bielefeld, Ctr Biotechnol, Inst Genome Res & Syst Biol, D-33615 Bielefeld, Germany

来源：

JOURNAL OF BACTERIOLOGY | 2012年 / 194卷 / 14期

关键词：

D O I：

10.1128/JB.00692-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

引用

页码：3756 / 3757

页数：2

共 8 条

[1] Primary metabolism and its control in streptomycetes: A most unusual group of bacteria [J].

Hodgson, DA .

ADVANCES IN MICROBIAL PHYSIOLOGY, VOL 42, 2000, 42 :47-238

[2]

Kieser T., 2000, PRACTICAL STREPTOMYC

[3] FK-506, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM A STREPTOMYCES .1. FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERISTICS [J].

KINO, T ;

HATANAKA, H ;

HASHIMOTO, M ;

NISHIYAMA, M ;

GOTO, T ;

OKUHARA, M ;

KOHSAKA, M ;

AOKI, H ;

IMANAKA, H .

JOURNAL OF ANTIBIOTICS, 1987, 40 (09) :1249-1255

[4] Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces [J].

Martin, Juan-Francisco ;

Liras, Paloma .

CURRENT OPINION IN MICROBIOLOGY, 2010, 13 (03) :263-273

[5] Efficient pyramidal arrangement of an ordered cosmid library: Rapid screening of genes of the tacrolimus-producer Streptomyces sp ATCC 55098 [J].

Martinez-Castro, Miriam ;

Solera, Elena ;

Martin, Juan F. ;

Barreiro, Carlos .

JOURNAL OF MICROBIOLOGICAL METHODS, 2009, 78 (02) :150-154

[6] antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences [J].

Medema, Marnix H. ;

Blin, Kai ;

Cimermancic, Peter ;

de Jager, Victor ;

Zakrzewski, Piotr ;

Fischbach, Michael A. ;

Weber, Tilmann ;

Takano, Eriko ;

Breitling, Rainer .

NUCLEIC ACIDS RESEARCH, 2011, 39 :W339-W346

[7] Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350 [J].

Ohnishi, Yasuo ;

Ishikawa, Jun ;

Hara, Hirofumi ;

Suzuki, Hirokazu ;

Ikenoya, Miwa ;

Ikeda, Haruo ;

Yamashita, Atsushi ;

Hattori, Masahira ;

Horinouchi, Sueharu .

JOURNAL OF BACTERIOLOGY, 2008, 190 (11) :4050-4060

[8] NRPSsp: non-ribosomal peptide synthase substrate predictor [J].

Prieto, Carlos ;

Garcia-Estrada, Carlos ;

Lorenzana, Diego ;

Francisco Martin, Juan .

BIOINFORMATICS, 2012, 28 (03) :426-427

← 1 →