Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography

被引：53

作者：

Chatni, Muhammad Rameez ^{[1
]}

Xia, Jun ^{[1
]}

Sohn, Rebecca ^{[2
]}

Maslov, Konstantin ^{[1
]}

Guo, Zijian ^{[1
]}

Zhang, Yu ^{[3
,4
]}

Wang, Kun ^{[1
]}

Xia, Younan ^{[3
,4
]}

Anastasio, Mark ^{[1
]}

Arbeit, Jeffrey ^{[2
]}

Wang, Lihong V. ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Washington Univ, Div Urol, Dept Surg, St Louis, MO 63130 USA

[3] Georgia Inst Technol, Atlanta, GA 30332 USA

[4] Emory Univ, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2012年 / 17卷 / 07期

基金：

美国国家卫生研究院;

关键词：

acousto-optics; image analysis; photoacoustic spectroscopy; INFRARED FLUORESCENT PROTEIN; RADIATION; PET; MICROSCOPY; EXPOSURE; SYSTEM; CT;

D O I：

10.1117/1.JBO.17.7.076012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.076012]

引用

页数：7

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