Electrophysiologic findings and grip strength after nerve injuries in the rat forelimb

被引：36

作者：

Wang, Huan ^{[2
,3
]}

Sorenson, Eric J. ^{[1
]}

Spinner, Robert J. ^{[2
]}

Windebank, Anthony J. ^{[1
]}

机构：

[1] Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Neurol Surg, Rochester, MN USA

[3] Fudan Univ, Huashan Hosp, Dept Hand Surg, Shanghai 20040, Peoples R China

来源：

MUSCLE & NERVE | 2008年 / 38卷 / 04期

基金：

美国国家卫生研究院;

关键词：

compound muscle action potential; grip strength; peripheral nerve; rat; somatosensory evoked potential;

D O I：

10.1002/mus.20971

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We developed electrophysiologic methods for testing the three major forelimb nerves as a tool to evaluate motor and sensory recovery in rats. Median, ulnar, or radial nerves were transected and repaired in Sprague-Dawley rats. Compound muscle action potentials (CMAPs) and somatosensory evoked potentials (SSEPs) were recorded preoperatively and at various postoperative intervals. Correlation between grip strength and CMAPs was investigated. Reliable CMAPs were recorded for all three nerves. Median- or ulnar-nerve-derived SSEPs were reliably recorded; radial SSEPs could not be recorded. CMAPs followed typical regeneration patterns after nerve repair. SSEPs showed a consistent peak latency but fluctuating amplitude. Grip strength and median CMAP amplitude correlated positively. We conclude that it is possible to conduct minimally invasive electrophysiologic testing in rat forelimbs. The CMAP is a valid parameter that shows the typical time course of nerve regeneration and reinnervation.

引用

页码：1254 / 1265

页数：12

共 53 条

[1] Functional recovery improvement is related to aberrant reinnervation trimming. A comparative study using fresh or predegenerated nerve grafts [J].

Augusto Bertelli, Jayme ;

Taleb, Madjid ;

Claude Mira, Jean ;

Flavio Ghizoni, Marcos .

ACTA NEUROPATHOLOGICA, 2006, 111 (06) :601-609

[2] Skilled forelimb reaching for pasta guided by tactile input in the rat as measured by accuracy, spatial adjustments, and force [J].

Ballermann, M ;

Tompkins, G ;

Whishaw, IQ .

BEHAVIOURAL BRAIN RESEARCH, 2000, 109 (01) :49-57

[3] EXPERIMENTAL INVESTIGATION OF CROSS-NERVE TRANSFERS RELATING TO REPAIR OF BRACHIAL-PLEXUS AVULSION INJURIES [J].

BATTISTON, B ;

GUIZZI, P ;

VIGASIO, A ;

BRUNELLI, G .

MICROSURGERY, 1990, 11 (02) :91-94

[4] Variation in nerve autograft length increases fibre misdirection and decreases pruning effectiveness. An experimental study in the rat median nerve [J].

Bertelli, JA ;

Taleb, M ;

Mira, JC ;

Ghizoni, MF .

NEUROLOGICAL RESEARCH, 2005, 27 (06) :657-665

[5] RAT BRACHIAL-PLEXUS AND ITS TERMINAL BRANCHES - AN EXPERIMENTAL-MODEL FOR THE STUDY OF PERIPHERAL-NERVE REGENERATION [J].

BERTELLI, JA ;

TALEB, M ;

SAADI, A ;

MIRA, JC ;

PECOTDECHAVASSINE, M .

MICROSURGERY, 1995, 16 (02) :77-85

[6] Long interpositional nerve graft consistently induces incomplete motor and sensory recovery in the rat - An experimental model to test nerve repair [J].

Bertelli, JA ;

dos Santos, ARS ;

Taleb, M ;

Calixto, JB ;

Mira, JC ;

Ghizoni, MF .

JOURNAL OF NEUROSCIENCE METHODS, 2004, 134 (01) :75-80

[7] BEHAVIORAL EVALUATING METHODS IN THE OBJECTIVE CLINICAL-ASSESSMENT OF MOTOR FUNCTION AFTER EXPERIMENTAL BRACHIAL-PLEXUS RECONSTRUCTION IN THE RAT [J].

BERTELLI, JA ;

MIRA, JC .

JOURNAL OF NEUROSCIENCE METHODS, 1993, 46 (03) :203-208

[8] Effects of intrathecal anandamide on somatosensory evoked responses in rats [J].

Bir, LS ;

Ercan, S .

EXPERIMENTAL NEUROLOGY, 2006, 197 (02) :386-390

[9] End-to-side nerve repair in the upper extremity of rat [J].

Bontioti, E ;

Kanje, M ;

Lundborg, G ;

Dahlin, LB .

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2005, 10 (01) :58-68

[10] Regeneration and functional recovery in the upper extremity of rats after various types of nerve injuries [J].

Bontioti, EN ;

Kanje, M ;

Dahlin, LB .

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2003, 8 (03) :159-168

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