Structural proteomics of dengue virus

被引：332

作者：

Perera, Rushika

Kuhn, Richard J. ^{[1
]}

机构：

[1] Purdue Univ, Markey Ctr Struct Biol, W Lafayette, IN 47907 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2008年 / 11卷 / 04期

关键词：

D O I：

10.1016/j.mib.2008.06.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle based on new structural data of the virus and its proteins. Specifically, we focus on the structure of the pre-membrane protein, prM and its role in virus assembly, the first full-length structure of a multi-domain dengue virus replication protein, NS3, and the recently solved structures of NS5 methyltransferase and polymerase domains. These structures provide a basis for describing function and predicting putative host interactions.

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页码：369 / 377

页数：9

相关论文

共 70 条

[1] Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold [J].

Aleshin, Alexander E. ;

Shiryaev, Sergey A. ;

Strongin, Alex Y. ;

Liddington, Robert C. .

PROTEIN SCIENCE, 2007, 16 (05) :795-806

[2] Functional characterization of cis and trans activity of the flavivirus NS2B-NS3 protease [J].

Bera, Aloke K. ;

Kuhn, Richard J. ;

Smith, Janet L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (17) :12883-12892

[3] A single positively selected West Nile viral mutation confers increased virogenesis in American crows [J].

Brault, Aaron C. ;

Huang, Claire Y-H ;

Langevin, Stanley A. ;

Kinney, Richard M. ;

Bowen, Richard A. ;

Ramey, Wanichaya N. ;

Panella, Nicholas A. ;

Holmes, Edward C. ;

Powers, Ann M. ;

Miller, Barry R. .

NATURE GENETICS, 2007, 39 (09) :1162-1166

[4] The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin β1 and importin α/β-recognized nuclear localization signals [J].

Brooks, AJ ;

Johansson, M ;

John, AV ;

Xu, YB ;

Jans, DA ;

Vasudevan, SG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (39) :36399-36407

[5] MUTAGENESIS OF THE YELLOW-FEVER VIRUS NS2B PROTEIN - EFFECTS ON PROTEOLYTIC PROCESSING, NS2B-NS3 COMPLEX-FORMATION, AND VIRAL REPLICATION [J].

CHAMBERS, TJ ;

NESTOROWICZ, A ;

AMBERG, SM ;

RICE, CM .

JOURNAL OF VIROLOGY, 1993, 67 (11) :6797-6807

[6] YELLOW-FEVER VIRUS PROTEIN-NS2A, PROTEIN-NS2B, AND PROTEIN-NS4B - IDENTIFICATION AND PARTIAL N-TERMINAL AMINO-ACID SEQUENCE-ANALYSIS [J].

CHAMBERS, TJ ;

MCCOURT, DW ;

RICE, CM .

VIROLOGY, 1989, 169 (01) :100-109

[7] PRODUCTION OF YELLOW-FEVER VIRUS PROTEINS IN INFECTED-CELLS - IDENTIFICATION OF DISCRETE POLYPROTEIN SPECIES AND ANALYSIS OF CLEAVAGE KINETICS USING REGION-SPECIFIC POLYCLONAL ANTISERA [J].

CHAMBERS, TJ ;

MCCOURT, DW ;

RICE, CM .

VIROLOGY, 1990, 177 (01) :159-174

[8] Antibodies against West Nile virus nonstructural protein NS1 prevent lethal infection through Fc γ receptor-dependent and -independent mechanisms [J].

Chung, KM ;

Nybakken, GE ;

Thompson, BS ;

Engle, MJ ;

Marri, A ;

Fremont, DH ;

Diamond, MS .

JOURNAL OF VIROLOGY, 2006, 80 (03) :1340-1351

[9] Cotranslational membrane insertion of the serine proteinase precursor NS2B-NS3(Pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B [J].

Clum, S ;

Ebner, KE ;

Padmanabhan, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (49) :30715-30723

[10] An RNA cap (nucleoside-2′-O-)-methyltransferase in the flavivirus RNA polymerase NS5:: crystal structure and functional characterization [J].

Egloff, MP ;

Benarroch, D ;

Selisko, B ;

Romette, JL ;

Canard, B .

EMBO JOURNAL, 2002, 21 (11) :2757-2768

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