Synthesis and cytotoxic evaluation of a series of genistein derivatives

被引：33

作者：

Li, HQ ^{[1
]}

Ge, HM ^{[1
]}

Chen, YX ^{[1
]}

Xu, C ^{[1
]}

Shi, L ^{[1
]}

Ding, H ^{[1
]}

Zhu, HL ^{[1
]}

Tan, RX ^{[1
]}

机构：

[1] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2006年 / 3卷 / 04期

关键词：

D O I：

10.1002/cbdv.200690049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thirty genistein (= 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one: GEN) derivatives were synthesized from genistein through a facile approach in high yields, Compounds 9. 11 12, 23-30 were reported for the first time, while 13-22 have already been reported in our recent paper. The cytotoxic activities of these compounds were evaluated against a human nasopharyngeal epidermoid tumor cell line KB. Compounds 7-9, 12, 14, 16-19, 21, 24, 27, 29 showed remarkable antitumor activities in vitro, which was comparable with 5-fluorouracil, an anticancer drug. On the basis of the obtained experimental data, structure-effect relationships were discussed.

引用

页码：463 / 472

页数：10

共 15 条

[1] Effect of natural and synthetic estrogens on A549 lung cancer cells: Correlation of chemical structures with cytotoxic effects [J].