Short-term regulation of insulin gene transcription

被引：14

作者：

Leibiger, B ^{[1
]}

Moede, T ^{[1
]}

Uhles, S ^{[1
]}

Berggren, PO ^{[1
]}

Leibiger, IB ^{[1
]}

机构：

[1] Karolinska Inst, Dept Mol Med, Rolf Luft Ctr Diabet Res, S-17176 Stockholm, Sweden

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2002年 / 30卷

关键词：

immediate early gene; insulin receptor; phosphoinositide; 3-kinase;

D O I：

10.1042/bst0300312

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Short-term regulation of insulin gene transcription is still a matter of debate. However, an increasing body of evidence shows that insulin gene transcription is affected by signals, such as incretins, glucose metabolites, intracellular Ca2+, and by insulin secreted from pancreatic beta-cells, all supporting the concept of an immediate response resulting in insulin gene transcription following food-Uptake. The present review aims to summarize the current view on the mechanisms underlying the up-regulation of insulin gene transcription in response to glucose, the major nutrient factor in insulin secretion and biosynthesis.

引用

页码：312 / 317

页数：6

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