Early Detection of Acute Mesenteric Ischemia Using Diffusion-Weighted 3.0-T Magnetic Resonance Imaging in a Porcine Model

被引:17
作者
Bruhn, Robin Sebastian [1 ]
Distelmaier, Martina Susanne [1 ]
Hellmann-Sokolis, Miriam [2 ]
Naami, Amjad [3 ]
Kuhl, Christiane Katharina [1 ]
Hohl, Christian [1 ]
机构
[1] Rhein Westfal TH Aachen, Univ Hosp, Dept Diagnost & Intervent Radiol, Aachen, Germany
[2] Univ Hosp, Inst Diagnost & Intervent Radiol & Neuroradiol, Essen, Germany
[3] Rhein Westfal TH Aachen, Univ Hosp, Inst Pathol, Aachen, Germany
关键词
diffusion-weighted magnetic resonance imaging; mesenteric vascular occlusion; angiography; digital subtraction; microspheres; INFLAMMATORY-BOWEL-DISEASE; REGIONAL CEREBRAL-ISCHEMIA; INTESTINAL ISCHEMIA; RAT-MODEL; STROKE; MRI; DIAGNOSIS; OCCLUSION; LACTATE; SENSE;
D O I
10.1097/RLI.0b013e3182809143
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: The aim of this study was to investigate if 3.0-T diffusion-weighted magnetic resonance imaging (MRI) can be used for early detection of acute occlusive and nonocclusive mesenteric ischemia. Materials and Methods: In this study, approved by the official committee on animal affairs, proximal (occlusive) mesenteric ischemia and peripheral (nonocclusive) mesenteric ischemia were induced in 8 and 2, respectively, female domestic pigs. Proximal mesenteric ischemia was induced by intraarterial injection of n-butyl-cyanoacrylate in the superior mesenteric artery or 1 of its main branches; peripheral mesenteric ischemia was induced by intra-arterial injection of microparticles. Before embolization and at 30-, 60-, and 90-minute intervals after embolization, diffusion-weighted imaging was performed, and apparent diffusion coefficient (ADC) maps were calculated on a clinical 3.0-T system. Immediately after the last MRI session, animals were killed to provide a pathological correlation for mesenteric ischemia. Results: Ischemic bowel parts appeared hyperintense on diffusion-weighted images and hypointense on the corresponding ADC maps. Mean diffusion-weighted imaging signal intensity increased and ADC decreased significantly within 30 minutes after embolization (P < 0.001) and remained unchanged until 90 minutes after injury, independent of the embolization method. Conclusions: 3.0-Tesla diffusion-weighted MRI may help detect acute mesenteric ischemia as early as 30 minutes after vessel occlusion.
引用
收藏
页码:231 / 237
页数:7
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