Irisin, a fascinating field in our times

被引：70
作者：
Bao, Jing-Fu [1 ,2 ]
She, Qin-Ying [3 ]
Hu, Pan-Pan [1 ,2 ]
Jia, Nan [1 ,2 ]
Li, Aiqing [1 ,2 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Natl Clin Res Ctr Kidney Dis, State Key Lab Organ Failure Res, Guangzhou 510515, Peoples R China
[2] Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangdong Prov Key Lab Renal Failure Res, Guangzhou 510005, Peoples R China
[3] Southern Med Univ, Affiliated Hosp 5, Dept Nephrol, Guangzhou 510999, Peoples R China
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2022年 / 33卷 / 09期
基金：
中国国家自然科学基金;
关键词：
MESSENGER-RNA EXPRESSION; SERUM IRISIN; AEROBIC EXERCISE; SKELETAL-MUSCLE; ADIPOSE-TISSUE; FNDC5; FAT; MYOKINE; GLUCOSE; DIFFERENTIATION;
D O I：
10.1016/j.tem.2022.06.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Irisin is a muscle-secreted hormone that is generated by cleavage of membrane protein FNDC-5 (fibronectin type III domain-containing protein 5). Irisin is considered to be a mediator of exercise-induced metabolic improvements, such as browning of white adipose tissue, and is known to alleviate several chronic non-metabolic diseases. Thus, irisin may be an ideal therapeutic target for metabolic and non-metabolic diseases. However, several controversies regarding irisin have hindered its clinical translation. We review the generation, regulation (especially in exercise), and metabolic as well as therapeutic effects of irisin on metabolic and non-metabolic diseases. Furthermore, we discuss controversies regarding irisin and highlight potential future research directions.
引用
收藏
页码：601 / 613
页数：13
相关论文
共 96 条
[1]   Irisin: Still chasing shadows [J].
Albrecht, Elke ;
Schering, Lisa ;
Buck, Friedrich ;
Vlach, Konrad ;
Schober, Hans-Christof ;
Drevon, Christian A. ;
Maak, Steffen .
MOLECULAR METABOLISM, 2020, 34 :124-135
[2]   Irisin - a myth rather than an exercise-inducible myokine [J].
Albrecht, Elke ;
Norheim, Frode ;
Thiede, Bernd ;
Holen, Torgeir ;
Ohashi, Tomoo ;
Schering, Lisa ;
Lee, Sindre ;
Brenmoehl, Julia ;
Thomas, Selina ;
Drevon, Christian A. ;
Erickson, Harold P. ;
Maak, Steffen .
SCIENTIFIC REPORTS, 2015, 5
[3]   A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues [J].
Aydin, Suleyman ;
Kuloglu, Tuncay ;
Aydin, Suna ;
Kalayci, Mehmet ;
Yilmaz, Musa ;
Cakmak, Tolga ;
Albayrak, Serdal ;
Gungor, Sami ;
Colakoglu, Neriman ;
Ozercan, Ibrahim Hanifi .
PEPTIDES, 2014, 61 :130-136
[4]   Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle [J].
Aydin, Suna ;
Kuloglu, Tuncay ;
Aydin, Suleyman ;
Eren, Mehmet Nesimi ;
Celik, Ahmet ;
Yilmaz, Musa ;
Kalayci, Mehmet ;
Sahin, Ibrahim ;
Gungor, Orhan ;
Gurel, Ali ;
Ogeturk, Murat ;
Dabak, Ozlem .
PEPTIDES, 2014, 52 :68-73
[5]   A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis [J].
Bostroem, Pontus ;
Wu, Jun ;
Jedrychowski, Mark P. ;
Korde, Anisha ;
Ye, Li ;
Lo, James C. ;
Rasbach, Kyle A. ;
Bostroem, Elisabeth Almer ;
Choi, Jang Hyun ;
Long, Jonathan Z. ;
Kajimura, Shingo ;
Zingaretti, Maria Cristina ;
Vind, Birgitte F. ;
Tu, Hua ;
Cinti, Saverio ;
Hojlund, Kurt ;
Gygi, Steven P. ;
Spiegelman, Bruce M. .
NATURE, 2012, 481 (7382) :463-U72
[6]  
Bubak Matthew P, 2017, Int J Exerc Sci, V10, P666
[7]   Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study [J].
Chen, Yanfei ;
Li, Mei ;
Liao, Binrong ;
Zhong, Jingzi ;
Lan, Dan .
ENDOCRINE CONNECTIONS, 2022, 11 (04)
[8]   Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging [J].
Chen, Yue ;
Ding, Jie ;
Zhao, Yufei ;
Ju, Shenghong ;
Mao, Hui ;
Peng, Xin-Gui .
EXPERIMENTAL BIOLOGY AND MEDICINE, 2021, 246 (14) :1597-1606
[9]   Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice [J].
Colaianni, Graziana ;
Mongelli, Teresa ;
Cuscito, Concetta ;
Pignataro, Paolo ;
Lippo, Luciana ;
Spiro, Giovanna ;
Notarnicola, Angela ;
Severi, Ilenia ;
Passeri, Giovanni ;
Mori, Giorgio ;
Brunetti, Giacomina ;
Moretti, Biagio ;
Tarantino, Umberto ;
Colucci, Silvia C. ;
Reseland, Janne E. ;
Vettor, Roberto ;
Cinti, Saverio ;
Grano, Maria .
SCIENTIFIC REPORTS, 2017, 7
[10]   The myokine irisin increases cortical bone mass [J].
Colaianni, Graziana ;
Cuscito, Concetta ;
Mongelli, Teresa ;
Pignataro, Paolo ;
Buccoliero, Cinzia ;
Liu, Peng ;
Lu, Ping ;
Sartini, Loris ;
Di Comite, Mariasevera ;
Mori, Giorgio ;
Di Benedetto, Adriana ;
Brunetti, Giacomina ;
Yuen, Tony ;
Sun, Li ;
Reseland, Janne E. ;
Colucci, Silvia ;
New, Maria I. ;
Zaidi, Mone ;
Cinti, Saverio ;
Grano, Maria .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (39) :12157-12162
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