Phenotype and Function of Human T Lymphocyte Subsets: Consensus and Issues

被引：574

作者：

Appay, Victor ^{[1
]}

van Lier, Rene A. W. ^{[2
]}

Sallusto, Federica ^{[3
]}

Roederer, Mario ^{[4
]}

机构：

[1] Univ Paris 06, Hop La Pitie Salpetriere, INSERM,Cellular Immunol Lab, U543,Avenir Grp, F-75013 Paris, France

[2] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1105 AZ Amsterdam, Netherlands

[3] Inst Res Biomed, CH-6500 Bellinzona, Switzerland

[4] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA

来源：

CYTOMETRY PART A | 2008年 / 73A卷 / 11期

关键词：

phenotype; function; T cells; virus;

D O I：

10.1002/cyto.a.20643

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, a tremendous effort has been devoted to the detailed characterization of the phenotype and function of distinct T cell subpopulations in humans, as well as to their pathway(s) of differentiation and role in immune responses. But these studies seem to have generated more questions than definitive answers. To clarify issues related to the function and differentiation of T cell subsets, one session of the MASIR 2008 conference was dedicated to this topic. Several points of consensus and discord were highlighted in the work presented during this session. We provide here all account of these points, including the relative heterogeneity of T cell subpopulations during infections with distinct pathogens, the relationship between phenotypic and functional T cell attributes, and the pathway(s) of T cell differentiation. Finally, we discuss the problems which still limit general agreement. Published 2008 Wiley-Liss, Inc.(dagger)

引用

页码：975 / 983

页数：9

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