The Central Role of Osteocytes in the Four Adaptive Pathways of Bone's Mechanostat

被引：45
作者：
Hughes, Julie M. [1 ]
Castellani, Colleen M. [1 ]
Popp, Kristin L. [1 ,2 ]
Guerriere, Katelyn, I [1 ]
Matheny, Ronald W., Jr. [1 ]
Nindl, Bradley C. [3 ]
Bouxsein, Mary L. [2 ,4 ,5 ]
机构：
[1] US Army Res Inst Environm Med, Mil Performance Div, 10 Gen Greene Ave,BLDG 42, Natick, MA 01760 USA
[2] Massachusetts Gen Hosp, Endocrine Unit, Boston, MA 02114 USA
[3] Univ Pittsburgh, Neuromuscular Res Lab, Warrior Human Performance Res Ctr, Dept Sports Med & Nutr, Pittsburgh, PA USA
[4] Beth Israel Deaconess Med Ctr, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
[5] Harvard Med Sch, Dept Orthopaed Surg, Boston, MA 02115 USA
来源：
EXERCISE AND SPORT SCIENCES REVIEWS | 2020年 / 48卷 / 03期
关键词：
bone functional adaptation; mechanical loading; mechanostat; osteocytes; disuse; modeling; remodeling; APOPTOSIS; RESORPTION; DISUSE; OSTEOPOROSIS; RECRUITMENT; ACTIVATION; STRENGTH; RANKL; MICE;
D O I：
10.1249/JES.0000000000000225
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
We review evidence supporting an updated mechanostat model in bone that highlights the central role of osteocytes within bone's four mechanoadaptive pathways: 1) formation modeling and 2) targeted remodeling, which occur with heightened mechanical loading, 3) resorption modeling, and 4) disuse-mediated remodeling, which occur with disuse. These four pathways regulate whole-bone stiffness in response to changing mechanical demands.
引用
收藏
页码：140 / 148
页数：9
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