Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine

被引：20

作者：

Cassiano, Chiara ^{[1
]}

Monti, Maria Chiara ^{[1
]}

Festa, Carmen ^{[2
]}

Zampella, Angela ^{[2
]}

Riccio, Raffaele ^{[1
]}

Casapullo, Agostino ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Sci Farmaceut & BioMed, I-84084 Salerno, Italy

[2] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

来源：

CHEMBIOCHEM | 2012年 / 13卷 / 13期

关键词：

heat shock protein 60; inhibitors; marine sesterterpene; mass spectrometry; proteomics; SPONGE COSCINODERMA-MATHEWSI; HEAT-SHOCK PROTEINS; NATURAL-PRODUCTS; MOLECULAR CHAPERONES; CITRATE SYNTHASE; INHIBITOR; BINDING; HSP60;

D O I：

10.1002/cbic.201200291

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Marine bioactive compounds are potential drug leads because of their diverse pharmacological effects against human diseases. The identification of their cellular targets is crucial for a rational approach to their application in medicinal chemistry. Thus, we have analyzed the cell interactome of suvanine, a sulfated tricyclic terpenoid of marine origin endowed with an interesting anti-inflammatory activity, by application of a chemical proteomic approach. Heat Shock Protein 60, a chaperone involved in the inflammatory response, is the main cellular target of suvanine, which is also able to interfere with protein chaperone activity, giving evidence for its anti-inflammatory properties.

引用

页码：1953 / 1958

页数：6

共 32 条

[1] HEAT-SHOCK PROTEINS AS MOLECULAR CHAPERONES
BECKER, J
CRAIG, EA
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 219 (1-2): : 11 - 23
[2] Marine natural products
Blunt, John W.
Copp, Brent R.
Hu, Wan-Ping
Munro, Murray H. G.
Northcote, Peter T.
Prinsep, Michele R.
[J]. NATURAL PRODUCT REPORTS, 2009, 26 (02) : 170 - 244
[3] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[4] Analysis of chaperone function using citrate synthase as nonnative substrate protein
Buchner, J
Grallert, H
Jakob, U
[J]. MOLECULAR CHAPERONES, 1998, 290 : 323 - 338
[5] GROE FACILITATES REFOLDING OF CITRATE SYNTHASE BY SUPPRESSING AGGREGATION
BUCHNER, J
SCHMIDT, M
FUCHS, M
JAENICKE, R
RUDOLPH, R
SCHMID, FX
KIEFHABER, T
[J]. BIOCHEMISTRY, 1991, 30 (06) : 1586 - 1591
[6] Protein phosphatase inhibitors isolated from Spongia irregularis collected in Papua New Guinea
Carr, Gavin
Raszek, Mikolaj
Van Soest, Rob
Matainaho, Teatulohi
Shopik, Micheal
Holmes, Charles F. B.
Andersen, Raymond J.
[J]. JOURNAL OF NATURAL PRODUCTS, 2007, 70 (11): : 1812 - 1815
[7] Chen W, 1999, J IMMUNOL, V162, P3212
[8] A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124
Dadvar, Poupak
O'Flaherty, Martina
Scholten, Arjen
Rumpel, Klaus
Heck, Albert J. R.
[J]. MOLECULAR BIOSYSTEMS, 2009, 5 (05) : 472 - 482
[9] Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties
De Marino, Simona
Festa, Carmen
D'Auria, Maria Valeria
Bourguet-Kondracki, Marie-Lise
Petek, Sylvain
Debitus, Cecile
Maria Andres, Rosa
Carmen Terencio, Maria
Paya, Miguel
Zampella, Angela
[J]. TETRAHEDRON, 2009, 65 (15) : 2905 - 2909
[10] Marine natural products as targeted modulators of the transcription factor NF-κB
Folmer, Florence
Jaspars, Marcel
Dicato, Mario
Diederich, Marc
[J]. BIOCHEMICAL PHARMACOLOGY, 2008, 75 (03) : 603 - 617

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