Elevated Levels of MMP-9 in Untreated Patients with Stage I Essential Hypertension

被引：10

作者：

Gkaliagkousi, Eugenia ^{[1
]}

Doumas, Michail ^{[1
]}

Gavriilaki, Eleni ^{[1
]}

Triantafyllou, Areti ^{[1
]}

Vogiatzis, Konstantinos ^{[1
]}

Anyfanti, Panagiota ^{[1
]}

Petidis, Konstantinos ^{[1
]}

Douma, Stella ^{[1
]}

机构：

[1] Hippokrateion Hosp, Propedeut Dept Internal Med 2, Thessaloniki, Greece

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2012年 / 34卷 / 08期

关键词：

metalloproteinases; MMP-2; MMP-9; TIMP-1; essential hypertension; MATRIX METALLOPROTEINASES; TISSUE INHIBITOR; ARTERIAL STIFFNESS; PLASMA MATRIX-METALLOPROTEINASE-9; CARDIOVASCULAR RISK; CD40; LIGAND; INTERLEUKIN-6; ASSOCIATION; EXPRESSION; COLLAGEN;

D O I：

10.3109/10641963.2012.681726

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Increased expression and activity of metalloproteinases have been implicated in the pathophysiology of vascular remodeling and in the growth of atherosclerotic lesions. We aimed at determining the levels of MMP-2, MMP-9, their specific inhibitors TIMP-2 and TIMP-1, and the inflammatory cytokines IL-6 and TNF-alpha, which are related to the stimulation of MMPs, in patients with untreated mild essential hypertension (UH) and normotensive (NT) volunteers. Serum MMP-9 and TIMP-1 levels were significantly different in UH volunteers when compared to NT volunteers. Thus, MMP-9 is elevated in the early stages of essential hypertension and may be used as a marker of cardiovascular risk and vascular dysfunction.

引用

页码：561 / 566

页数：6

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