Genetics and Biology of Pancreatic Ductal Adenocarcinoma

被引：60

作者：

Dunne, Richard F. ^{[1
]}

Hezel, Aram F. ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Wilmot Canc Inst, Div Hematol Oncol, Rochester, NY 14642 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2015年 / 29卷 / 04期

关键词：

Pancreatic Cancer; KRAS; Microenvironment; Stroma; Immunomodulation; Autophagy; TUMOR-SUPPRESSOR GENE; ONCOGENIC KRAS; INTRAEPITHELIAL NEOPLASIA; MOUSE MODEL; TGF-BETA; CANCER-CELLS; E-CADHERIN; AUTOPHAGY; HEDGEHOG; GROWTH;

D O I：

10.1016/j.hoc.2015.04.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma remains a clinical challenge. Thus far, enlightenment on the downstream activities of Kras, the tumor's unique metabolic needs, and how the stroma and immune system affect it have remained untranslated to the clinical practice. Given the numbers of diverse therapies in development and a growing knowledge about how to evaluate these systems preclinically and clinically, this is expected to change significantly and for the better over the next 5 years.

引用

页码：595 / +

页数：15

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