Copper-catalyzed three-component reaction of N-heteroaryl aldehydes, nitriles, and water

被引：12
作者：
Bao, Hanyang [1 ]
Zhou, Bingwei [1 ]
Jin, Hongwei [1 ]
Liu, Yunkui [1 ]
机构：
[1] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Zhejiang, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 20期
关键词：
RADICAL CYCLIZATION; CASCADE REACTIONS; PHENANTHRIDINE DERIVATIVES; QUINOXALINE DERIVATIVES; REGIOSPECIFIC SYNTHESIS; UNACTIVATED ALKENES; BOND-CLEAVAGE; DIFUNCTIONALIZATION; ALKYNES; TRIFLUOROMETHYLATION;
D O I：
10.1039/c9ob00599d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and straightforward method for the synthesis of N-heteroaroyl imides has been successfully developed involving a copper-catalyzed radical-triggered three-component reaction of N-heteroaryl aldehydes, nitriles, and water. Mechanistic studies indicate that the reaction may undergo a radical-triggered Ritter-type reaction in which water serves as the oxygen source for the formation of the C-O bond. The reaction has advantages such as a broad substrate scope for the N-heteroaryl aldehydes, atom economy, and simple operation.
引用
收藏
页码：5021 / 5028
页数：8
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