Copper-catalyzed three-component reaction of N-heteroaryl aldehydes, nitriles, and water

被引：12

作者：

Bao, Hanyang ^{[1
]}

Zhou, Bingwei ^{[1
]}

Jin, Hongwei ^{[1
]}

Liu, Yunkui ^{[1
]}

机构：

[1] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 20期

关键词：

RADICAL CYCLIZATION; CASCADE REACTIONS; PHENANTHRIDINE DERIVATIVES; QUINOXALINE DERIVATIVES; REGIOSPECIFIC SYNTHESIS; UNACTIVATED ALKENES; BOND-CLEAVAGE; DIFUNCTIONALIZATION; ALKYNES; TRIFLUOROMETHYLATION;

D O I：

10.1039/c9ob00599d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and straightforward method for the synthesis of N-heteroaroyl imides has been successfully developed involving a copper-catalyzed radical-triggered three-component reaction of N-heteroaryl aldehydes, nitriles, and water. Mechanistic studies indicate that the reaction may undergo a radical-triggered Ritter-type reaction in which water serves as the oxygen source for the formation of the C-O bond. The reaction has advantages such as a broad substrate scope for the N-heteroaryl aldehydes, atom economy, and simple operation.

引用

收藏

页码：5021 / 5028

页数：8

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