Transforming growth factor-beta gene polymorphism in sarcoidosis and tuberculosis patients

被引：0

作者：

Niimi, T

Sato, S

Sugiura, Y

Yoshinouchi, T

Akita, K

Maeda, H

Achiwa, H

Ninomiya, S

Akita, Y

Suzuki, M

Nishio, M

Yoshikawa, K

Morishita, M

Shimizu, S

Ueda, R

机构：

[1] Nagoya City Univ, Sch Med, Dept Internal Med 2, Mizuho Ku, Nagoya, Aichi 467, Japan

[2] Nagoya Daini Red Cross Hosp, Dept Resp Dis, Nagoya, Aichi, Japan

[3] Daido Hosp, Dept Resp Dis, Nagoya, Aichi, Japan

[4] Aichi Med Univ, Sch Med, Dept Internal Med 2, Nagakute, Aichi 48011, Japan

[5] Nagoya City Univ, Sch Med, Dept Pathol 2, Nagoya, Aichi 467, Japan

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2002年 / 6卷 / 06期

关键词：

TGF-beta; gene; polymorphism; sarcoidosis; tuberculosis;

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

SETTING: Transforming growth factor-beta (TGF-beta) plays an important role in many diseases, influencing as it does such processes as immune responses, fibrosing processes, and angiogenesis. Recently, polymorphisms have been described for TGF-beta that are associated with the risk of several diseases. In this study, we investigated whether TGF-beta1 polymorphism has an effect on sarcoidosis and tuberculosis. OBJECTIVE: TGF-beta1 Codon 10 T869C polymorphism was investigated in 110 healthy control subjects, 104 sarcoidosis patients, and 101 tuberculosis patients. DESIGN: The TGF-beta genotype was determined using polymerase chain reaction restriction fragment length polymorphism. RESULTS: We found no significant differences in TGF-beta genotypes between sarcoidosis patients and healthy controls or tuberculosis patients and controls. The long axis of the tuberculin skin test was larger in the CC type compared with the CT type. However, there was no association between the TGF-beta genotype and the roentgenographic stage, the disappearance of shadows, or organ involvement in sarcoidosis, nor any association between genotype, the extent or type of roentgenographic shadow, or detected volume of tubercle bacilli in tuberculosis. CONCLUSION: From the results, we believe that TGF-beta polymorphisms on the whole do not have a strong influence on disease onset or clinical progression in sarcoidosis and tuberculosis, although this polymorphism might have an effect on the immune response in a tuberculosis host.

引用

页码：510 / 515

页数：6

共 23 条

[11] Vitamin D receptor gene polymorphism in patients with sarcoidosis [J].

Niimi, T ;

Tomita, H ;

Sato, S ;

Kawaguchi, H ;

Akita, K ;

Maeda, H ;

Sugiura, Y ;

Ueda, R .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (04) :1107-1109

[12] Circulating TNF-α, TGF-β, and IL-10 in tuberculosis patients and healthy contacts [J].

Olobo, JO ;

Geletu, M ;

Demissie, A ;

Eguale, T ;

Hiwot, K ;

Aderaye, G ;

Britton, S .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2001, 53 (01) :85-91

[13] Interaction of Mycobacterium tuberculosis-induced transforming growth factor β1 and interleukin-10 [J].

Othieno, C ;

Hirsch, CS ;

Hamilton, BD ;

Wilkinson, K ;

Ellner, JJ ;

Toossi, Z .

INFECTION AND IMMUNITY, 1999, 67 (11) :5730-5735

[14]

Ravikumar M., 1999, Tubercle and Lung Disease, V79, P309, DOI 10.1054/tuld.1999.0213

[15] Transforming growth factor-β1 in sarcoidosis [J].

Salez, F ;

Gosset, P ;

Copin, MC ;

Degros, CL ;

Tonnel, AB ;

Wallaert, B .

EUROPEAN RESPIRATORY JOURNAL, 1998, 12 (04) :913-919

[16]

Selvaraj P., 1999, Tubercle and Lung Disease, V79, P221, DOI 10.1054/tuld.1999.0204

[17] Evidence that genetic susceptibility to Mycobacterium tuberculosis in a Brazilian population is under oligogenic control: linkage study of the candidate genes NRAMP1 and TNFA [J].

Shaw, MA ;

Collins, A ;

Peacock, CS ;

Miller, EN ;

Black, GF ;

Sibthorpe, D ;

Lins-Lainson, Z ;

Shaw, JJ ;

Ramos, F ;

Silveira, F ;

Blackwell, JM .

TUBERCLE AND LUNG DISEASE, 1997, 78 (01) :35-45

[18] The role of TGFβ in the pathogenesis of human tuberculosis [J].

Toossi, Z ;

Ellner, JJ .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1998, 87 (02) :107-114

[19] Examining a paradox in the pathogenesis of human pulmonary tuberculosis: immune activation and suppression/anergy [J].

Vanham, G ;

Toossi, Z ;

Hirsch, CS ;

Wallis, RS ;

Schwander, SK ;

Rich, EA ;

Ellner, JJ .

TUBERCLE AND LUNG DISEASE, 1997, 78 (3-4) :145-158

[20] Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study [J].

Wilkinson, RJ ;

Llewelyn, M ;

Toossi, Z ;

Patel, P ;

Pasvol, G ;

Lalvani, A ;

Wright, D ;

Latif, M ;

Davidson, RN .

LANCET, 2000, 355 (9204) :618-621

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