MicroRNA-206: The skeletal muscle-specific myomiR

被引:324
|
作者
McCarthy, John J. [1 ]
机构
[1] Univ Kentucky, Med Ctr, Dept Physiol, Lexington, KY 40536 USA
关键词
MicroRNA; Skeletal muscle; Satellite cell; Fiber-type; Circadian;
D O I
10.1016/j.bbagrm.2008.03.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myro =muscle+ miR= miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:682 / 691
页数:10
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