PET/CT Scanner and Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Diffuse Large B-Cell Lymphoma

被引：24

作者：

El Karak, Fadi ^{[1
]}

Bou-Orm, Ibrahim R. ^{[1
]}

Ghosn, Marwan ^{[1
]}

Kattan, Joseph ^{[1
]}

Farhat, Fadi ^{[1
]}

Ibrahim, Toni ^{[1
]}

Jreige, Mario ^{[2
]}

El Cheikh, Jean ^{[3
]}

Haidar, Mohamad ^{[4
,5
]}

机构：

[1] St Joseph Univ USJ, Sch Med, Beirut, Lebanon

[2] CHU Vaudois, Dept Nucl Med, Lausanne, Switzerland

[3] Amer Univ Beirut, Med Ctr, Dept Hematol, Beirut, Lebanon

[4] Amer Univ Beirut, Med Ctr, Dept Radiol, Beirut, Lebanon

[5] Mt Lebanon Hosp, Dept Nucl Med, Beirut, Lebanon

来源：

PLOS ONE | 2017年 / 12卷 / 01期

关键词：

D O I：

10.1371/journal.pone.0170299

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Evaluation of bone marrow involvement (BMI) is paramount in diffuse large B-cell lymphoma (DLBCL) for prognostic and therapeutic reasons. PET/CT scanner (PET) is now a routine examination for the staging of DLBCL with prognostic and therapeutic implications. This study evaluates the role of PET for detecting marrow involvement compared to bone marrow biopsy (BMB). This monocentric study included 54 patients diagnosed with DLBCL between 2009 and 2013 and who had FDG PET/CT in a pre-treatment setting. A correlation analysis of the detection of BMI by PET and BMB was performed. A prognostic evaluation of BMI by BMB and/or PET/CT and correlation with an overall 2-year survival were analyzed. PET was more sensitive for the detection of BMI than BMB (92.3% vs. 38.5%). It can be considered a discriminatory Pre-BMB test with a negative predictive value of 97.6%. In addition, BMI by PET had a prognostic value with strong correlation with progression-free survival (PFS) (HR = 3.81; p = 0.013) and overall survival (OS) (HR = 4.12; p = 0.03) while the BMB had not. PET shows superior performance to the BMB for the detection of marrow involvement in DLBCL. It may be considered as the first line examination of bone marrow instead of the biopsy.

引用

页数：8

共 11 条

[1] Bone marrow biopsy in diffuse large B-cell lymphoma: Useful or redundant test? [J].