Effect of renal denervation procedure on left ventricular hypertrophy of hypertensive rats and its mechanisms

被引：17

作者：

Jiang, Weihong ^{[1
]}

Tan, Lihua ^{[1
]}

Guo, Yunzhong ^{[1
]}

Li, Xiaogang ^{[1
]}

Tang, Xiaohong ^{[1
]}

Yang, Kan ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 3, Dept Cardiol, Changsha 410013, Hunan, Peoples R China

来源：

ACTA CIRURGICA BRASILEIRA | 2012年 / 27卷 / 11期

关键词：

Denervation; Kidney; Hypertrophy; Left Ventricular; Toll-Like Receptor 4; Ventricular Remodeling; Norepinephrine; Rats; RESISTANT HYPERTENSION; CARDIAC-HYPERTROPHY; NEURAL-CONTROL; INFLAMMATION; MYOCARDIUM; KIDNEY; HEART;

D O I：

10.1590/S0102-86502012001100012

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

PURPOSE: To investigate the effect of renal denervation (RDN) on the blood pressure, left ventricular hypertrophy and myocardial expression of TLR4/NF-kappa B in spontaneously hypertensive rats (SHR). METHODS: A total of 36 SHR were randomly assigned into control group (D0), RDN group (D) and sham group (S). 12 WKY rats of same age served as controls (WKY group). Rats in the D0 and WKY groups were sacrificed, but rats in the D and S group were sacrificed at one week and six weeks after surgery. The heart was collected and the left ventricle weighted followed by calculation of left ventricular mass index (LVMI). RESULTS: In the D0 group, the blood pressure, LVMI and protein expression of TLR4, NF-kappa B, TNF-alpha and IL-6 in the myocardium were markedly higher than that in the WKY group (p<0.05). In the D1 and D2 group, the LVMI, NE and protein expression of TLR4, NF-kappa B, TNF-alpha and IL-6 in the myocardium were significantly reduced (p<0.05). CONCLUSION: Renal denervation can significantly delay the progression of left ventricular hypertrophy in spontaneously hypertensive rats, which may be attributed to the not only the suppression of sympathetic activity and attenuation of pressure load but the improvement of myocardial immuno-inflammation.

引用

页码：815 / 820

页数：6

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