Brain hemorrhages after rt-PA treatment of embolic stroke in spontaneously hypertensive rats

被引：34

作者：

Brinker, G ^{[1
]}

Pillekamp, F ^{[1
]}

Hossmann, KA ^{[1
]}

机构：

[1] Max Planck Inst Neurol Forsch, Abt Expt Neurol, D-50931 Cologne, Germany

来源：

NEUROREPORT | 1999年 / 10卷 / 09期

关键词：

hemorrhage; middle cerebral artery occlusion; spontaneously hypertensive rats; thrombolysis; thromboembolic stroke;

D O I：

10.1097/00001756-199906230-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

INTRACEREBRAL hemorrhage is a major complicating factor of thrombolytic therapy of stroke. To investigate the incidence of bleeding in animals with a diseased vascular system, thrombolysis was carried out in spontaneously hypertensive rats (SHR) after clot embolism of the right middle cerebral artery (MCA). Three hours after embolism SHR were treated with either recombinant tissue-plasminogen activator (rt-PA) or saline, and neurological deficits and intracerebral hemorrhages were evaluated after 3 days survival. Rt-PA-treated SHR exhibited a significantly higher incidence of hemorrhages than untreated rats but neurological deficits and survival rates showed a non-significant trend for improvement. This model offers the possibility of investigating the pathophysiology of post-thrombolytic complications in a clinically relevant small animal model. NeuroReport 10:1943-1946 (C) 1999 Lippincott Williams & Wilkins.

引用

页码：1943 / 1946

页数：4

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