Efficient synthesis of 1-alkyl-2,3,4,5-tetramethoxy-6-methylbenzene: key intermediate for preparing coenzyme Q analogues

被引：2

作者：

Fan, Lei ^{[1
]}

Wang, Jin ^{[2
]}

Liao, Teng-huo-sheng ^{[3
]}

机构：

[1] Childrens Hosp Zhengzhou City, Dept Pharm, Zhengzhou 450053, Peoples R China

[2] Univ Toulouse 3, Univ Toulouse, F-31062 Toulouse 9, France

[3] Zhejiang MENOVO Pharmaceut Co LTD, Shangyu 312300, Zhejiang, Peoples R China

来源：

ARKIVOC | 2015年

关键词：

Coenzyme Q; Kornblum oxidation; one-pot tandem reaction; aromatic nitrile; IDEBENONE; UBIQUINONE; OXIDATION; MEMBRANE; CHAIN;

D O I：

10.3998/ark.5550190.p009.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper described a convenient and efficient route for the synthesis of 1-alkyl-2, 3, 4, 5-tetramethoxy-6-methylbenzene, which are the key intermediate for the synthesis of C-6 substituted Coenzyme Q analogues. All the reactions are operationally simple and amenable to gram-scale synthesis.

引用

页码：242 / 247

页数：6

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