SURGICAL DEBRIDEMENT PLUS TOPICAL CYCLOSPORINE A IN THE TREATMENT OF VERNAL SHIELD ULCERS

被引:8
作者
Caputo, R. [1 ]
Pucci, N. [2 ]
Mori, F. [2 ]
De Libero, C. [1 ]
Di Grande, L. [2 ]
Bacci, G. M. [1 ]
机构
[1] Univ Florence, Pediat Ophthalmol Unit, Anna Meyer Childrens Hosp, Dept Pediat, Florence, Italy
[2] Univ Florence, Allergy & Clin Immunol Unit, Anna Meyer Childrens Hosp, Dept Pediat, Florence, Italy
来源
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2012年 / 25卷 / 03期
关键词
vernal keratoconjunctivitis; vernal shield ulcers; cyclosporine eye drops; surgical debridement; 2-PERCENT CYCLOSPORINE; KERATOCONJUNCTIVITIS; MANAGEMENT; EFFICACY; PLAQUES; CONJUNCTIVITIS; EYEDROPS; CORNEA; SAFETY;
D O I
10.1177/039463201202500326
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Vernal Keratoconjunctivitis (VKC) is a severe chronic bilateral inflammation of the ocular surface characterized by seasonal exacerbations. Long-term prognosis is generally good; however, 6% develop sequelae responsible for permanent visual impairment. Corneal involvement is almost always present, consisting of punctate keratitis, shield ulcers (3-11%) and late corneal neovascularization. In recent years, topical cyclosporine A preparations at 2% in oil or at 1% in polyvinyl alcohol, have been successfully proposed for long term VKC treatments. It has been previously proven that medical treatment is not always sufficient, especially when it is employed to treat shield ulcer plaques. In such conditions, surgery may be effective for avoiding long term complications such as amblyopia, strabismus, infections and corneal perforation. In this paper, we show the efficacy of surgical debridement by means of simple scraping associated with topical cyclosporine treatment for the management of vernal shield ulcers complicated with plaques.
引用
收藏
页码:775 / 780
页数:6
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