Synthesis of uracil derivatives and some of their reactions

被引：0

作者：

Barmaki, M. ^{[1
]}

Maharramov, A. M. ^{[1
]}

Allakhverdiev, M. A. ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, North Branch, Tehran, Iran

来源：

ASIAN JOURNAL OF CHEMISTRY | 2008年 / 20卷 / 07期

关键词：

ethyl cyanoacetate; thiocarbamide; 1-phenylcarbamide-3-hydroxy-4,6-pyrimidine-[2,3-a]-5'-hydroxy-tetrahydro-1,3-thiazine;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot synthesis of 1-phenylcarbamide-3-hydroxy-4,6-pyrimidine-[2,3-a]-5'-hydroxytetrahydro-1,3-thiazine is described. The synthesis is based on the reaction of ethyl cyanoacetate and thiocarbamide in the presence of sodium acetate. The cyclized compounds react with 1,2-epoxychloropropane then treated in medium of ethyl alcohol in peresence of KOH, which recyclized product 1-amino-3-hydroxy-4,6-pyrimidine-[2,3-a]-5'-hydroxy-tetrahydro-1,3-thiazine produced. In the final reaction, this product with phenylisocyanate give a side chain reaction of the obtained 1-phenylcarbamide-3-hydroxy-4,6-pyrimidine-[2,3-a]-5'-hydroxytetrahydro-1,3-thiazine.

引用

页码：5277 / 5281

页数：5

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