Effect of 5-hydroxytryptamine infusion on microcirculation in the rabbit masseter muscle measured by laser-Doppler flowmetry

被引：2

作者：

Kurita, H

Ernberg, M

Tominaga, K

Alstergren, P

Kopp, S

机构：

[1] Karolinska Inst, Fac Dent, Dept Clin Oral Physiol, S-14104 Huddinge, Sweden

[2] Shinshu Univ, Sch Med, Dept Dent & Oral Surg, Matsumoto, Nagano 3900802, Japan

[3] Kyushu Dent Coll, Dept Oral & Maxillofacial Surg 1, Kitakyushu, Fukuoka 802, Japan

来源：

ARCHIVES OF ORAL BIOLOGY | 1999年 / 44卷 / 05期

关键词：

serotonin; microcirculation; muscle; laser-Doppler flowmetry; rabbit;

D O I：

10.1016/S0003-9969(99)00019-9

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The aim was to test the hypothesis that 5-hydroxytryptamine (5-HT) influences the microcirculation of the masseter muscle. Rabbit masseters were infused with increasing concentrations of 5-HT (10(-9)-10(-5) M) on the experimental side and with saline on the control side. The effect on microcirculatory blood flow was measured by laser-Doppler flowmetry. The intramuscular temperature was recorded to monitor the influence of tissue temperature. 5-HT infusion resulted in a statistically significant decrease in blood flow at the lowest concentration (10(-9) M) (median; -11.2%. Wilcoxon signed-rank test; p < 0.05). At concentrations greater than 10(-9) M, there was no significant change in blood flow. This study shows a decrease of microcirculatory blood flow in the rabbit masseter following 5-HT infusion (10(-9) M). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：377 / 382

页数：6