A phase I study of subcutaneously administered aflibercept (VEGF trap) in a new formulation in patients with advanced solid tumors

被引：5

作者：

Wang-Gillam, Andrea ^{[1
]}

Tew, William P. ^{[2
]}

Rothenberg, Mace L. ^{[3
,5
]}

Dupont, Jakob ^{[2
]}

Cooper, Wendy ^{[3
]}

Sternas, Lars ^{[4
]}

Buzenet, Giliane ^{[4
]}

Sosman, Jeffrey A. ^{[3
]}

Spriggs, David R. ^{[2
]}

Lockhart, Albert Craig ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63110 USA

[2] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[3] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[4] Sanofi Aventis Oncol, Bridgewater, NJ USA

[5] Pfizer Inc, New York, NY USA

来源：

INVESTIGATIONAL NEW DRUGS | 2012年 / 30卷 / 05期

关键词：

Phase I study; Aflibercept; Angiogenesis inhibitor; Subcutaneously administration; GROWTH-FACTOR-TRAP; ASCITES;

D O I：

10.1007/s10637-011-9753-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Targeting angiogenesis is a valid anti-cancer strategy. Aflibercept is designed to sequester circulating vascular endothelial growth factor (VEGF) by preventing VEGF from binding to its receptors. This phase I study was to evaluate a new formulation of subcutaneously administered aflibercept in patients with advanced solid tumors. Here we report our experience with the toxicity, pharmacokinetic profile and efficacy of the new 100 mg/mL subcutaneous (SC) formulation of aflibercept administered at a dose of at 4 mg/kg every 2 weeks.

引用

页码：1958 / 1961

页数：4

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