共 25 条
Oxidized low-density lipoprotein inhibits the degradation of cyclophilin A via the lysosome in vascular smooth muscle cells
被引:4
作者:

Su, Zizhuo
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Lin, Maohuan
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Su, Yinqing
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Li, Jiajie
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Lin, Rongjie
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Wu, Maoxiong
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Wang, Xiaoyu
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Huang, Lili
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Chen, Yuyang
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Shu, Xiaorong
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Liang, Shumin
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Zhang, Haifeng
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Huang, Tucheng
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Nie, Ruqiong
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Wang, Jingfeng
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China

Xie, Shuanglun
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
机构:
[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China
[2] Guangdong Prov Key Lab Arrhythmia & Electrophysio, Guangzhou 510120, Guangdong, Peoples R China
来源:
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
|
2020年
/
12卷
/
07期
基金:
美国国家科学基金会;
关键词:
Oxidized low-density lipoprotein;
cyclophilin A;
RNA interference;
cycloheximide;
lysosome;
atherosclerotic plaques;
AUTOPHAGY;
PROTEIN;
UBIQUITINATION;
MECHANISMS;
EMMPRIN;
D O I:
暂无
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Background: Cyclophilin A (CyPA) plays an important role in the progression of atherosclerosis. Additionally, it has been reported that lysosomal function is markedly impaired in atherosclerosis induced by oxidized low-density lipoprotein (ox-LDL). As the CyPA degradation pathway remains to be elucidated, we aimed to uncover the role of lysosomes and ox-LDL in the degradation of CyPA. Methods: We exploited RNA interference (RNAi) in combination with either the lysosomal inhibitor chloroquine (CQ) or the proteasomal inhibitor MG-132 to examine CyPA turnover. We also investigated the role of ox-LDL in lysosomal function and the CyPA degradation pathway and determined whether CyPA interacts with the selective autophagy adaptor p62. Results: CQ markedly reversed the CyPA down-regulation induced by RNAi and increased intracellular levels of LC3 and p62. MG-132 significantly suppressed polyubiquitinated protein degradation but did not inhibit RNAi-induced CyPA downregulation. Additionally, neither CQ nor MG-132 influenced the gene-silencing efficiency of CyPA siRNA. Moreover, ox-LDL induced cytosolic accu-mulation of p62 was inconsistent with increased expression of LC3-II. Meanwhile, ox-LDL inhibited RNAi-induced downregulation of CyPA. Immunofluorescence indicated colocalization of endogenous CyPA with ubiquitin and with p62 in response to CQ treatment, and co-immunoprecipitation analysis confirmed interaction between CyPA and p62. Conclusion: CyPA is degraded by a lysosome-dependent pathway that may involve p62-mediated selective autophagy. Furthermore, ox-LDL modulates the degradation of CyPA via its inhibitory role in lysosomes, contributing to increased expression of CyPA in atherosclerotic plaques.
引用
收藏
页码:3964 / 3973
页数:10
相关论文
共 25 条
[1]
Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation
[J].
Allavena, Giulia
;
Boyd, Caroline
;
Oo, Kyaw Soe
;
Maellaro, Emilia
;
Zhivotovsky, Boris
;
Kaminskyy, Vitaliy O.
.
AUTOPHAGY,
2016, 12 (11)
:2085-2097

Allavena, Giulia
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden
Univ Siena, Dept Mol & Dev Med, Siena, Italy Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden

Boyd, Caroline
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden

Oo, Kyaw Soe
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden

Maellaro, Emilia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Siena, Dept Mol & Dev Med, Siena, Italy Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden

Zhivotovsky, Boris
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden
Moscow MV Lomonosov State Univ, Fac Basic Med, Moscow, Russia Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden

Kaminskyy, Vitaliy O.
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, SE-17177 Stockholm, Sweden
[2]
Disease-Associated Mutations of TDP-43 Promote Turnover of the Protein Through the Proteasomal Pathway
[J].
Araki, Wataru
;
Minegishi, Seiji
;
Motoki, Kazumi
;
Kume, Hideaki
;
Hohjoh, Hirohiko
;
Araki, Yumiko M.
;
Tamaoka, Akira
.
MOLECULAR NEUROBIOLOGY,
2014, 50 (03)
:1049-1058

Araki, Wataru
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan

Minegishi, Seiji
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan

Motoki, Kazumi
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan

Kume, Hideaki
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan

Hohjoh, Hirohiko
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mol Pharmacol, Kodaira, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan

Araki, Yumiko M.
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan
Juntendo Univ, Grad Sch Med, Dept Psychiat & Behav Sci, Tokyo 1138421, Japan Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan

Tamaoka, Akira
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tsukuba, Fac Med, Dept Neurol, Tsukuba, Ibaraki 3058575, Japan Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan
[3]
Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688
[J].
El Ayadi, Amina
;
Stieren, Emily S.
;
Barral, Jose M.
;
Boehning, Darren
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2012, 109 (33)
:13416-13421

El Ayadi, Amina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA

Stieren, Emily S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA

Barral, Jose M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA
Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA
Univ Texas Med Branch, Mitchell Ctr Neurodegenerat Dis, Galveston, TX 77555 USA Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA

Boehning, Darren
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA
Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA
Univ Texas Med Branch, Mitchell Ctr Neurodegenerat Dis, Galveston, TX 77555 USA
Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA
[4]
Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae
[J].
Emanuel, Roy
;
Sergin, Ismail
;
Bhattacharya, Somashubhra
;
Turner, Jaleisa N.
;
Epelman, Slava
;
Settembre, Carmine
;
Diwan, Abhinav
;
Ballabio, Andrea
;
Razani, Babak
.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,
2014, 34 (09)
:1942-1952

Emanuel, Roy
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

Sergin, Ismail
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

Bhattacharya, Somashubhra
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

Turner, Jaleisa N.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

Epelman, Slava
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

Settembre, Carmine
论文数: 0 引用数: 0
h-index: 0
机构:
Telethon Inst Genet & Med TIGEM, Naples, Italy
Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

Diwan, Abhinav
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA
John Cochran VA Med Ctr, St Louis, MO USA Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

Ballabio, Andrea
论文数: 0 引用数: 0
h-index: 0
机构:
Telethon Inst Genet & Med TIGEM, Naples, Italy
Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

Razani, Babak
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA
[5]
Molecular Mechanisms of Autophagy in the Cardiovascular System
[J].
Gatica, Damian
;
Chiong, Mario
;
Lavandero, Sergio
;
Klionsky, Daniel J.
.
CIRCULATION RESEARCH,
2015, 116 (03)
:456-467

Gatica, Damian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

Chiong, Mario
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chile, Fac Chem & Pharmaceut Sci, Fac Med, Adv Ctr Chron Dis ACCDiS, Santiago, Chile
Univ Chile, Fac Chem & Pharmaceut Sci, Fac Med, Ctr Mol Studies Cell CEMC, Santiago, Chile Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

论文数: 引用数:
h-index:
机构:

Klionsky, Daniel J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
[6]
Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression
[J].
Giegerich, Annika Klara
;
Kuchler, Laura
;
Sha, Lisa Katharina
;
Knape, Tilo
;
Heide, Heinrich
;
Wittig, Ilka
;
Behrends, Christian
;
Bruene, Bernhard
;
von Knethen, Andreas
.
AUTOPHAGY,
2014, 10 (11)
:1937-1952

Giegerich, Annika Klara
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany

Kuchler, Laura
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany

Sha, Lisa Katharina
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany

Knape, Tilo
论文数: 0 引用数: 0
h-index: 0
机构:
Fraunhofer IME Project Grp Translat Med & Pharmac, Frankfurt, Germany Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany

Heide, Heinrich
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Fac Med, Funct Prote Core Unit SFB815, D-60054 Frankfurt, Germany Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany

Wittig, Ilka
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Fac Med, Funct Prote Core Unit SFB815, D-60054 Frankfurt, Germany Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany

论文数: 引用数:
h-index:
机构:

Bruene, Bernhard
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, Fac Med, D-60054 Frankfurt, Germany

论文数: 引用数:
h-index:
机构:
[7]
Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity
[J].
Haller, Martina
;
Hock, Andreas K.
;
Giampazolias, Evangelos
;
Oberst, Andrew
;
Green, Douglas R.
;
Debnath, Jayanta
;
Ryan, Kevin M.
;
Vousden, Karen H.
;
Tait, Stephen W. G.
.
AUTOPHAGY,
2014, 10 (12)
:2269-2278

Haller, Martina
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland
Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

Hock, Andreas K.
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

Giampazolias, Evangelos
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland
Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

Oberst, Andrew
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

Green, Douglas R.
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

Debnath, Jayanta
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94140 USA Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

Ryan, Kevin M.
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

Vousden, Karen H.
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

Tait, Stephen W. G.
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland
Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland
[8]
Ubiquitin depletion as a key mediator of toxicity by translational inhibitors
[J].
Hanna, J
;
Leggett, DS
;
Finley, D
.
MOLECULAR AND CELLULAR BIOLOGY,
2003, 23 (24)
:9251-9261

Hanna, J
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Leggett, DS
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Finley, D
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[9]
Selective autophagy mediated by autophagic adapter proteins
[J].
Johansen, Terje
;
Lamark, Trond
.
AUTOPHAGY,
2011, 7 (03)
:279-296

Johansen, Terje
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tromso, Inst Med Biol, Mol Canc Res Grp, Tromso, Norway Univ Tromso, Inst Med Biol, Mol Canc Res Grp, Tromso, Norway

Lamark, Trond
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tromso, Inst Med Biol, Mol Canc Res Grp, Tromso, Norway Univ Tromso, Inst Med Biol, Mol Canc Res Grp, Tromso, Norway
[10]
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
[J].
Kang, Chanhee
;
Xu, Qikai
;
Martin, Timothy D.
;
Li, Mamie Z.
;
Demaria, Marco
;
Aron, Liviu
;
Lu, Tao
;
Yankner, Bruce A.
;
Campisi, Judith
;
Elledge, Stephen J.
.
SCIENCE,
2015, 349 (6255)

Kang, Chanhee
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA

Xu, Qikai
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA

Martin, Timothy D.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA

Li, Mamie Z.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA

Demaria, Marco
论文数: 0 引用数: 0
h-index: 0
机构:
Buck Inst Res Aging, Novato, CA 94945 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA

Aron, Liviu
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA

Lu, Tao
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA

Yankner, Bruce A.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA

Campisi, Judith
论文数: 0 引用数: 0
h-index: 0
机构:
Buck Inst Res Aging, Novato, CA 94945 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA

Elledge, Stephen J.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Div Genet,Brigham & Womens Hosp,Howard Hughes Med, Boston, MA 02115 USA