Increased circulating apoptotic lymphocytes in children with Down syndrome

被引：10

作者：

Gemen, Eugenie F. A. ^{[2
]}

Verstegen, Ruud H. J. ^{[1
]}

Leuvenink, Jacqueline ^{[2
]}

de Vries, Esther ^{[1
]}

机构：

[1] Jeroen Bosch Hosp, Dept Pediat, NL-5200 ME Shertogenbosch, Netherlands

[2] Jeroen Bosch Hosp, Lab Clin Chem & Haematol, NL-5200 ME Shertogenbosch, Netherlands

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 07期

关键词：

apoptosis; Down syndrome; immunology; lymphocytes; INTRINSIC DEFECT; BLOOD; CELLS; SUBPOPULATIONS; COUNTS;

D O I：

10.1002/pbc.24246

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Down syndrome (DS) resembles immunodeficiency with increased infections, auto-immune diseases, and hematological malignancies. Until now, immunological studies in DS mainly focused on T-lymphocytes. We recently described a profound B-lymphocytopenia in children with DS. This could be caused by increased apoptosis. Therefore, we determined expression of flowcytometric markers for apoptosis [Annexin-V (AV) and propidium iodide (PI)] on peripheral lymphocytes in 72 children with DS and 32 age-matched controls (AMC). Within the total lymphocyte compartment, apoptosis was more pronounced in DS; it increased with age. Moreover, apoptosis was highest within the B-lymphocyte compartment which may be a contributing factor to the B-lymphocytopenia found in DS. Pediatr Blood Cancer 2012; 59: 13101312.(C) 2012 Wiley Periodicals, Inc.

引用

页码：1310 / 1312

页数：3

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