Complex interactions between the DNA-damage response and mammalian telomeres

被引：153
作者：
Arnoult, Nausica [1 ]
Karlseder, Jan [1 ]
机构：
[1] Salk Inst Biol Studies, Dept Mol & Cellular Biol, La Jolla, CA 92037 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2015年 / 22卷 / 11期
基金：
美国国家卫生研究院;
关键词：
STRAND BREAK REPAIR; PROTECTS HUMAN TELOMERES; HUMAN-CELLS; DYSFUNCTIONAL TELOMERES; LIGASE III; END; TRF2; FUSION; RECOMBINATION; RAP1;
D O I：
10.1038/nsmb.3092
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural chromosome ends resemble double-stranded DNA breaks, but they do not activate a damage response in healthy cells. Telomeres therefore have evolved to solve the 'end-protection problem' by inhibiting multiple DNA damage response pathways. During the past decade, the view of telomeres has progressed from simple caps that hide chromosome ends to complex machineries that have an active role in organizing the genome. Here we focus on mammalian telomeres and summarize and interpret recent discoveries in detail, focusing on how repair pathways are inhibited, how resection and replication are controlled and how these mechanisms govern cell fate during senescence, crisis and transformation.
引用
收藏
页码：859 / 866
页数：8
相关论文
共 100 条
  • [71] SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates
    Sarkar, Jaya
    Wan, Bingbing
    Yin, Jinhu
    Vallabhaneni, Haritha
    Horvath, Kent
    Kulikowicz, Tomasz
    Bohr, Vilhelm A.
    Zhang, Yanbin
    Lei, Ming
    Liu, Yie
    [J]. NUCLEIC ACIDS RESEARCH, 2015, 43 (12) : 5912 - 5923
  • [72] Human RAP1 inhibits non-homologous end joining at telomeres
    Sarthy, Jay
    Bae, Nancy S.
    Scrafford, Jonathan
    Baumann, Peter
    [J]. EMBO JOURNAL, 2009, 28 (21) : 3390 - 3399
  • [73] Removal of Shelterin Reveals the Telomere End-Protection Problem
    Sfeir, Agnel
    de lange, Titia
    [J]. SCIENCE, 2012, 336 (6081) : 593 - 597
  • [74] Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal
    Sfeir, Agnel
    Kabir, Shaheen
    van Overbeek, Megan
    Celli, Giulia B.
    de Lange, Titia
    [J]. SCIENCE, 2010, 327 (5973) : 1657 - 1661
  • [75] Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
    Sfeir, Agnel
    Kosiyatrakul, Settapong T.
    Hockemeyer, Dirk
    MacRae, Sheila L.
    Karlseder, Jan
    Schildkraut, Carl L.
    de lange, Titia
    [J]. CELL, 2009, 138 (01) : 90 - 103
  • [76] Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma
    Shi, Jianxin
    Yang, Xiaohong R.
    Ballew, Bari
    Rotunno, Melissa
    Calista, Donato
    Fargnoli, Maria Concetta
    Ghiorzo, Paola
    Paillerets, Brigitte Bressac-de
    Nagore, Eduardo
    Avri, Marie Francoise
    Caporaso, Neil E.
    McMaster, Mary L.
    Cullen, Michael
    Wang, Zhaoming
    Zhang, Xijun
    Bruno, William
    Pastorino, Lorenza
    Queirolo, Paola
    Banuls-Roca, Jose
    Garcia-Casado, Zaida
    Vaysse, Amaury
    Mohamdi, Hamida
    Riazalhosseini, Yasser
    Foglio, Mario
    Jouenne, Fanelie
    Hual, Xing
    Hyland, Paula L.
    Yin, Jinhu
    Vallabhaneni, Haritha
    Chai, Weihang
    Minghetti, Paola
    Pellegrini, Cristina
    Ravichandran, Sarangan
    Eggermont, Alexander
    Lathrop, Mark
    Peris, Ketty
    Scarra, Giovanna Bianchi
    Landi, Giorgio
    Savage, Sharon A.
    Sampson, Joshua N.
    He, Ji
    Yeager, Meredith
    Goldin, Lynn R.
    Demenais, Florence
    Chanockl, Stephen J.
    Tucker, Margaret A.
    Goldsteinl, Alisa M.
    Liu, Yie
    Landi, Maria Teresa
    [J]. NATURE GENETICS, 2014, 46 (05) : 482 - 486
  • [77] Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients
    Simpson, K.
    Jones, R. E.
    Grimstead, J. W.
    Hills, R.
    Pepper, C.
    Baird, D. M.
    [J]. MOLECULAR ONCOLOGY, 2015, 9 (06) : 1186 - 1193
  • [78] DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2
    Smogorzewska, A
    Karlseder, J
    Holtgreve-Grez, H
    Jauch, A
    de Lange, T
    [J]. CURRENT BIOLOGY, 2002, 12 (19) : 1635 - 1644
  • [79] Different telomere damage signaling pathways in human and mouse cells
    Smogorzewska, A
    de Lange, T
    [J]. EMBO JOURNAL, 2002, 21 (16) : 4338 - 4348
  • [80] Stansel RM, 2001, EMBO J, V20, P5532
12345678910