Substrate-promoted copper-catalyzed N-arylation of amino alcohols with aryl iodides in water

被引：8

作者：

Jin, Ming ^{[1
]}

Zhao, Dan ^{[1
]}

He, Guozhen ^{[1
]}

Tong, Yao ^{[1
]}

Han, Shiqing ^{[1
]}

机构：

[1] Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF CATALYSIS | 2013年 / 34卷 / 09期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Amino alcohol; Aqueous phase; Copper catalyst; N-Arylation reaction; Substrate promotion; NITROGEN-CONTAINING HETEROCYCLES; BOND-FORMING REACTIONS; O-ARYLATION; EFFICIENT; HALIDES; LIGAND; MILD; AMINATION; BROMIDES; AMIDATION;

D O I：

10.1016/S1872-2067(12)60623-8

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient method has been developed for the N-arylation of a variety of water-soluble amino alcohols (1.2 mmol) with aryl iodides (1.0 mmol) in water under CuI-catalyzed conditions. The reaction was conducted via substrate-promoted action and did not require an additional ligand or phase-transfer catalyst, and afforded the desired N-aryl amines in acceptable to excellent yields (64%-93%) under mild reaction conditions with a small excess of the amino alcohol. (C) 2013, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：1651 / 1655

页数：5

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