Focus on prolactin as a metabolic hormone

被引：259

作者：

Ben-Jonathan, N ^{[1
]}

Hugo, ER ^{[1
]}

Brandebourg, TD ^{[1
]}

LaPensee, CR ^{[1
]}

机构：

[1] Univ Cincinnati, Sch Med, Dept Cell Biol, Cincinnati, OH 45267 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2006年 / 17卷 / 03期

关键词：

D O I：

10.1016/j.tem.2006.02.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

New information about the effects of prolactin (PRL) on metabolic processes warrants re-evaluation of the overall metabolic actions of PRL. PRL affects metabolic homeostasis by regulating key enzymes and transporters that are associated with glucose and lipid metabolism in several target organs. In the lactating mammary gland, PRL increases the production of milk proteins, lactose and lipids. In adipose tissue, PRL generally suppresses lipid storage and adipokine release. PRL supports the growth of pancreatic islets, stimulates insulin secretion and increases citrate production in the prostate. A specific case is made for PRL in the human breast and adipose tissue, where it acts as a circulating hormone and an autocrine or paracrine factor. Although the overall effects of PRL on body composition are modest and species specific, PRL might be involved in the manifestation of insulin resistance.

引用

页码：110 / 116

页数：7

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