Double cord blood transplantation in patients with high risk bone marrow failure syndromes

被引：38
作者：
Ruggeri, A. [1 ,2 ,3 ]
de Latour, R. Peffault [1 ]
Rocha, V. [1 ,2 ]
Larghero, J. [4 ]
Robin, M. [1 ]
Rodrigues, C. A. [1 ]
Traineau, R. [5 ]
Ribaud, P. [1 ]
Ferry, C. [1 ]
Devergie, A. [1 ]
Gluckman, E. [2 ]
Socie, G. [1 ]
机构：
[1] Univ Paris 07, Hop St Louis, APHP, Serv Hematol Greffe, F-75010 Paris, France
[2] Hop St Louis, APHP, Clin Res Unit, Eurocord Off, Paris, France
[3] Univ Vita Salute San Raffaele, Haematol & Bone Marrow Transplantat Unit, Milan, Italy
[4] Univ Paris 07, Hop St Louis, APHP, Unite Therapie Cellulaire, F-75010 Paris, France
[5] Univ Paris 07, Hop St Louis, APHP, Serv Hemobiol, F-75010 Paris, France
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 143卷 / 03期
关键词：
double cord blood transplantation; bone marrow failure; Fanconi anaemia; severe aplastic anaemia;
D O I：
10.1111/j.1365-2141.2008.07364.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Patients with bone marrow failure syndromes (BMFS) who reject a first allogeneic transplant or fail immunosuppressive therapy (IST) have an especially grim prognosis. We report 14 patients (eight adults, six children) transplanted with double cord blood transplantation (dUCBT) for BMFS. Neutrophil recovery was observed in eight patients, with full donor chimerism of one unit, and acute GVHD in 10. With a median follow-up of 23 months, the estimated 2 years overall survival was 80 +/- 17% and 33 +/- 16% for patients with acquired and inherited BMFS, respectively. Transplantation of two partially HLA-matched UCB thus enables salvage treatment of high-risk patients with BMFS.
引用
收藏
页码：404 / 408
页数：5
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