Double cord blood transplantation in patients with high risk bone marrow failure syndromes

被引：38
作者：
Ruggeri, A. [1 ,2 ,3 ]
de Latour, R. Peffault [1 ]
Rocha, V. [1 ,2 ]
Larghero, J. [4 ]
Robin, M. [1 ]
Rodrigues, C. A. [1 ]
Traineau, R. [5 ]
Ribaud, P. [1 ]
Ferry, C. [1 ]
Devergie, A. [1 ]
Gluckman, E. [2 ]
Socie, G. [1 ]
机构：
[1] Univ Paris 07, Hop St Louis, APHP, Serv Hematol Greffe, F-75010 Paris, France
[2] Hop St Louis, APHP, Clin Res Unit, Eurocord Off, Paris, France
[3] Univ Vita Salute San Raffaele, Haematol & Bone Marrow Transplantat Unit, Milan, Italy
[4] Univ Paris 07, Hop St Louis, APHP, Unite Therapie Cellulaire, F-75010 Paris, France
[5] Univ Paris 07, Hop St Louis, APHP, Serv Hemobiol, F-75010 Paris, France
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 143卷 / 03期
关键词：
double cord blood transplantation; bone marrow failure; Fanconi anaemia; severe aplastic anaemia;
D O I：
10.1111/j.1365-2141.2008.07364.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Patients with bone marrow failure syndromes (BMFS) who reject a first allogeneic transplant or fail immunosuppressive therapy (IST) have an especially grim prognosis. We report 14 patients (eight adults, six children) transplanted with double cord blood transplantation (dUCBT) for BMFS. Neutrophil recovery was observed in eight patients, with full donor chimerism of one unit, and acute GVHD in 10. With a median follow-up of 23 months, the estimated 2 years overall survival was 80 +/- 17% and 33 +/- 16% for patients with acquired and inherited BMFS, respectively. Transplantation of two partially HLA-matched UCB thus enables salvage treatment of high-risk patients with BMFS.
引用
收藏
页码：404 / 408
页数：5
相关论文
共 50 条
  • [31] Immunological Basis of Bone Marrow Failure after Allogeneic Hematopoietic Stem Cell Transplantation
    Masouridi-Levrat, Stavroula
    Simonetta, Federico
    Chalandon, Yves
    FRONTIERS IN IMMUNOLOGY, 2016, 7
  • [32] Abnormal metabolites related to bone marrow failure in aplastic anemia patients
    Zhong, P.
    Zhang, J.
    Cui, X.
    GENETICS AND MOLECULAR RESEARCH, 2015, 14 (04) : 13709 - 13718
  • [33] Cord Blood Unit Dominance Analysis and Effect of the Winning Unit on Outcomes after Double-Unit Umbilical Cord Blood Transplantation in Adults with Acute Leukemia: A Retrospective Study on Behalf of Eurocord, the Cord Blood Committee of Cellular Therapy, Immunobiology Working Party, and the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    Tozatto-Maio, Karina
    Giannotti, Federica
    Labopin, Myriam
    Ruggeri, Annalisa
    Volt, Fernanda
    Paviglianiti, Annalisa
    Kenzey, Chantal
    Hayashi, Hiromi
    Cornelissen, Jan
    Michallet, Mauricette
    Karakasis, Dimitrios
    Deconinck, Eric
    Rohrlich, Pierre-Simon
    de la Tour, Regis Peffault
    Blaise, Didier
    Petersen, Eefke
    D'Aveni, Maud
    Sengeloev, Henrik
    Lamy, Thierry
    Russell, Nigel H.
    Forcade, Edouard
    Craddock, Charles F.
    Nagler, Arnon
    Gluckman, Eliane
    Rocha, Vanderson
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2018, 24 (08) : 1657 - 1663
  • [34] Diagnostic efficacy of next-generation sequencing panel testing in the diagnosis of inherited bone marrow failure syndromes
    Scocchia, Alicia
    Kokkonen, Paivi
    Hirvonen, Elina
    Martensson, Emma
    Duzkale, Hatice
    Gall, Kim
    Jacher, Joe
    Saarinen, Inka
    Sistonen, Johanna
    Koskenvuo, Juha
    Koskinen, Lotta
    Alastalo, Tero-Pekka
    JOURNAL OF CLINICAL IMMUNOLOGY, 2021, 41 (SUPPL 1) : S61 - S62
  • [35] Role of the mesenchymal stromal cells in bone marrow failure of Fanconi Anemia patients
    Zubicaray, Josune
    Ivanova, Maria
    Iriondo, June
    Martinez, Jorge Garcia
    Munoz-Viana, Rafael
    Abad, Lorea
    Garcia-Garcia, Lorena
    Gonzalez de Pablo, Jesus
    Galvez, Eva
    Sebastian, Elena
    Ramirez, Manuel
    Madero, Luis
    Diaz, Miguel Angel
    Gonzalez-Murillo, Africa
    Sevilla, Julian
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2024, 12
  • [36] NKG2D-mediated immunity underlying paroxysmal nocturnal haemoglobinuria and related bone marrow failure syndromes
    Hanaoka, Nobuyoshi
    Nakakuma, Hideki
    Horikawa, Kentaro
    Nagakura, Shoichi
    Tsuzuki, Yasuchika
    Shimanuki, Masaya
    Kojima, Kensuke
    Yonemura, Yuji
    Kawaguchi, Tatsuya
    BRITISH JOURNAL OF HAEMATOLOGY, 2009, 146 (05) : 538 - 545
  • [37] Myeloid Neoplasms With Germline Predisposition Are Not Uncommon Among Cohorts of Patients With Bone Marrow Failure
    Viswanathan, Ganesh Kumar
    Dass, Jasmita
    Aggarwal, Mukul
    Kumar, Pradeep
    Seth, Tulika
    Goel, Harsh
    Tanwar, Pranay
    Dhawan, Rishi
    Mahapatra, Manoranjan
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2024, 24 : S328 - S328
  • [38] Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes
    Danielle M. Townsley
    Ronan Desmond
    Cynthia E. Dunbar
    Neal S. Young
    International Journal of Hematology, 2013, 98 : 48 - 55
  • [39] Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes
    Townsley, Danielle M.
    Desmond, Ronan
    Dunbar, Cynthia E.
    Young, Neal S.
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2013, 98 (01) : 48 - 55
  • [40] Excessive production of tumor necrosis factor-alpha by bone marrow T lymphocytes is essential in causing bone marrow failure in patients with aplastic anemia
    Hara, T
    Ando, K
    Tsurumi, H
    Moriwaki, H
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2004, 73 (01) : 10 - 16
12345