Genetic association of Toll-like receptor 4 gene and coronary artery disease in a Chinese Han population

被引：10

作者：

Zhou, Liting ^{[1
]}

Zheng, Dongchun ^{[1
]}

Wang, Shuyue ^{[3
]}

Zhu, Jian ^{[1
]}

Jia, Yiyang ^{[1
]}

Sun, Di ^{[1
]}

Xu, Jin ^{[1
]}

Wang, Qi ^{[1
]}

Chen, Huaiji ^{[1
]}

Xu, Feng ^{[1
]}

Li, Bo ^{[2
]}

Ye, Lin ^{[1
]}

机构：

[1] Jilin Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, 1163 Xin Min St, Changchun 130021, Peoples R China

[2] Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Stat, 1163 Xin Min St, Changchun 130021, Peoples R China

[3] Jilin Univ, China Japan Union Hosp, Dept Emergency, Changchun, Peoples R China

来源：

SPRINGERPLUS | 2016年 / 5卷

关键词：

Coronary artery disease; Gene polymorphism; Toll-like receptor 4; MYOCARDIAL-INFARCTION; ASP299GLY POLYMORPHISM; JAPANESE SUBJECTS; PROSTATE-CANCER; NORMAL-TENSION; HEART-DISEASE; TLR4; RISK; INFLAMMATION; EXPRESSION;

D O I：

10.1186/s40064-016-3177-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Purpose: Toll-like receptor 4 (TLR4) is known to be involved in innate immunity and inflammatory responses that play important roles in the pathogenesis of coronary artery disease (CAD). But the relationship between TLR4 gene and CAD has yet to be investigated. The present study aimed to evaluate the association of TLR4 gene polymorphisms with CAD susceptibility in a Chinese Han population. Methods: A total of 1094 subjects (577 unrelated patients with CAD and 517 controls) were recruited between 2008 and 2012. Three tag SNPs (rs1927907, rs1927911 and rs11536889) present in the TLR4 gene were genotyped using Sequenom Mass-ARRAY system. Results: The genotypic distributions of the three SNPs were not deviate from Hardy-Weinberg equilibrium. There was no significant difference in distributions of allelic frequencies of each SNPs between healthy controls and CAD patients (P > 0.05). Genotype frequencies of TLR4 gene did not show any statistically significant difference between the two groups in co-dominant, dominant or recessive genetic models (P > 0.05). The frequency of haplotypes in the case group was similar to that in the control group (P > 0.05). Conclusion: TLR4 gene do not relate to genetic susceptibility of CAD in the Chinese Han population.

引用

页数：7

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