Bioavailability of phytochemicals and its enhancement by drug delivery systems

被引：233

作者：

Aqil, Farrukh ^{[1
]}

Munagala, Radha ^{[1
]}

Jeyabalan, Jeyaprakash ^{[1
]}

Vadhanam, Manicka V. ^{[1
]}

机构：

[1] Univ Louisville, James Graham Brown Canc Ctr, Louisville, KY 40202 USA

来源：

CANCER LETTERS | 2013年 / 334卷 / 01期

关键词：

Chemoprevention; Bioavailability; Nanochemoprevention; Drug delivery; Polymeric implant; Nanoparticles; BLOCK-COPOLYMER MICELLES; IN-VIVO EVALUATION; POLY(BETA-AMINO ESTER) NANOPARTICLES; PEGYLATED LIPOSOMAL DOXORUBICIN; TUMOR-TARGETED DELIVERY; PH-SENSITIVE SYSTEM; POLYMERIC MICELLES; ORAL BIOAVAILABILITY; PLGA NANOPARTICLES; ANTITUMOR-ACTIVITY;

D O I：

10.1016/j.canlet.2013.02.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Issues of poor oral bioavailability of cancer chemopreventives have hindered progress in cancer prevention. Novel delivery systems that modulate the pharmacokinetics of existing drugs, such as nanoparticles, cyclodextrins, niosomes, liposomes and implants, could be used to enhance the delivery of chemopreventive agents to target sites. The development of new approaches in prevention and treatment of cancer could encompass new delivery systems for approved and newly investigated compounds. In this review, we discuss some of the delivery approaches that have already made an impact by either delivering a drug to target tissue or increasing its bioavailability by many fold. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：133 / 141

页数：9

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