Bone marrow-derived stromal cell therapy for traumatic brain injury is neuroprotective via stimulation of non-neurologic organ systems

被引：47

作者：

Walker, Peter A. ^{[1
,2
]}

Shah, Shinil K. ^{[1
,2
,3
]}

Jimenez, Fernando ^{[1
]}

Aroom, Kevin R. ^{[2
]}

Harting, Matthew T. ^{[4
]}

Cox, Charles S., Jr. ^{[1
,2
,3
]}

机构：

[1] Univ Texas Med Sch Houston, Dept Pediat Surg, Houston, TX 77030 USA

[2] Univ Texas Med Sch Houston, Dept Surg, Houston, TX 77030 USA

[3] Texas A&M Univ, Michael E DeBakey Inst Comparat Cardiovasc Sci &, College Stn, TX USA

[4] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA

来源：

SURGERY | 2012年 / 152卷 / 05期

关键词：

GROWTH-FACTOR;

D O I：

10.1016/j.surg.2012.06.006

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Bone marrow-derived mesenchymal stromal cells (MSCs) used as "MSC therapy" after traumatic brain injury act as remote "bioreactors" via stimulation of lung macrophages and augmention of T regulatory cell production by the spleen, leading to systemic increases in circulating anti-inflammatory cytokines and alteration of the locoregional milieu of the central nervous system. The altered intracerebral microenvironment leads to modulation of the resident microglia population, thereby stimulating an increase in the ratio of M2 (anti-inflammatory) macrophage to M1 (proinflammatory) macrophage, and it is this effect that accounts for the observed neuroprotection. (Surgery 2012; 152:790-3.)

引用

页码：790 / 793

页数：4

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