Physical Activity and Amyloid- Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment

ObjectivesTo examine the associations between amyloid- brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. DesignCross-sectional study. SettingFrench community-dwelling people. ParticipantsElderly adults with normal or mildly impaired cognition (mean age 74.74.2; 60.4% female) with available information on current self-reported PA and amyloid- brain deposition measured using positron emission tomography (PET) using the PET-ligand florbetapir F 18 (n=268). MeasurementsA standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR-). ResultsBivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR- participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E epsilon 4 carriers or noncarriers. PA was not associated with cognitive function. ConclusionAlthough PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid- brain deposition. Further studies are needed to determine whether PA (ideally measured at several time-points using objective measures) is involved in the pathophysiology of Alzheimer's disease.