New hetero-oligomeric peptide nucleic acids with improved binding properties to complementary DNA

被引：47
|
作者：
Jordan, S
Schwemler, C
Kosch, W
Kretschmer, A
Stropp, U
Schwenner, E
Mielke, B
机构：
[1] Bayer AG, Central Research
[2] Bayer AG, Pharma Research Center
[3] Biotest AG, D-63303 Dreieich
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 06期
关键词：
D O I：
10.1016/S0960-894X(97)00085-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hetero-oligomeric PNAs consisting of new monomeric building blocks and various amounts of N-(2-aminoethyl) glycine have been synthesized by solid-phase chemistry. Some of these new compounds show stronger binding to complementary DNA than the original PNAs, and are consequently very interesting candidates as antisense compounds for applications in therapy and in diagnostics. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：687 / 690
页数：4
相关论文
共 50 条
  • [21] STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA
    HYRUP, B
    EGHOLM, M
    NIELSEN, PE
    WITTUNG, P
    NORDEN, B
    BUCHARDT, O
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (18) : 7964 - 7970
  • [22] Inhibition of a DNA-helicase by peptide nucleic acids
    Bastide, L
    Boehmer, PE
    Villani, G
    Lebleu, B
    NUCLEIC ACIDS RESEARCH, 1999, 27 (02) : 551 - 554
  • [23] Recognition of RNA and DNA targets by peptide nucleic acids
    Corey, DR
    Pitts, A
    Simmons, C
    Mayfield, L
    Hamilton, S
    PEPTIDES FOR THE NEW MILLENNIUM, 2000, : 788 - 789
  • [24] Designed peptide with peptide nucleic acids for addressable precipitation of silica on DNA
    Usui, Kenji
    Nagai, Kazuma
    Nishiyama, Hiroto
    Endoh, Tamaki
    Tsuruoka, Takaaki
    Fujii, Satoshi
    PROTEIN SCIENCE, 2012, 21 : 122 - 123
  • [25] Structural and functional characterization of self-assembled monolayers of peptide nucleic acids and its interaction with complementary DNA
    Briones, C
    Mateo-Martí, E
    Gómez-Navarro, C
    Parro, V
    Román, E
    Martín-Gago, JA
    JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2005, 228 (1-2) : 131 - 136
  • [26] PEPTIDE NUCLEIC-ACIDS CONTAINING ADENINE OR GUANINE RECOGNIZE THYMINE AND CYTOSINE IN COMPLEMENTARY-DNA SEQUENCES
    EGHOLM, M
    BEHRENS, C
    CHRISTENSEN, L
    BERG, RH
    NIELSEN, PE
    BUCHARDT, O
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (09) : 800 - 801
  • [27] A new method for the synthesis of peptide nucleic acids
    Wexselblatt, E.
    Yavin, E.
    Katzhendler, J.
    Vaksman, O.
    Reich, R.
    CHEMISTRY OF NUCLEIC ACID COMPONENTS, 2008, 10 : 471 - 472
  • [28] Computationally de novo designed peptide-mediated hetero-oligomeric interactions for modular self-assembly of protein and lipoprotein nanostructures
    Ardejani, Maziar
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [29] Medicinal chemistry of plasmid DNA with peptide nucleic acids: A new strategy for gene therapy
    Zelphati, O
    Felgner, J
    Wang, Y
    Liang, XW
    Wang, XD
    Felgner, P
    LETTERS IN PEPTIDE SCIENCE, 2003, 10 (3-4): : 309 - 323
  • [30] Olefinic peptide nucleic acids (OPAs):: New aspects of the molecular recognition of DNA by PNA
    Schütz, R
    Cantin, M
    Roberts, C
    Greiner, B
    Uhlmann, E
    Leumann, C
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2000, 39 (07) : 1250 - +
12345