Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle

被引：20

作者：

Li, Yong ^{[1
,2
]}

Liu, Yun-Bao ^{[1
,2
]}

Yan, Hui-Min ^{[1
,2
]}

Liu, Yang-Lan ^{[1
,2
]}

Li, Yu-Huan ^{[2
,3
]}

Lv, Hai-Ning ^{[1
,2
]}

Ma, Shuang-Gang ^{[1
,2
]}

Qu, Jing ^{[1
,2
]}

Yu, Shi-Shan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci, Inst Med, Biotechnol, Beijing 100050, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国国家自然科学基金;

关键词：

SKELETON; DERIVATIVES; GRAYANOIDS; ROOTS;

D O I：

10.1038/srep36752

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two new grayanoids, rhodomollin A (1) and rhodomollin B (2), possessing an unprecedented D-homo grayanane carbon skeleton, were isolated from the fruits of Rhododendron molle. The structures of 1 and 2 were fully characterized using a combination of spectroscopic analyses and X-ray crystallography. Rhodomollin B (2) exhibited modest activity against influenza virus A/95-359, with an IC50 value of 19.24 mu M.

引用

页数：6

共 21 条

[1] KALMANOL, A PHARMACOLOGICALLY ACTIVE DITERPENOID WITH A NEW RING SKELETON FROM KALMIA-ANGUSTIFOLIA L [J].