In silico screening for tumour-specific expressed sequences in human genome

被引：40

作者：

Baranova, AV

Lobashev, AV

Ivanova, DV

Krukovskaya, LL

Yankovsky, NK

Kozlov, AP

机构：

[1] Res Inst Pure Biochem, Biomed Ctr, St Petersburg 197110, Russia

[2] Vavilov Inst Gen Genet, Moscow 119991, Russia

来源：

FEBS LETTERS | 2001年 / 508卷 / 01期

关键词：

computer-based differential display; cancer; gene expression;

D O I：

10.1016/S0014-5793(01)03028-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output rile of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：143 / 148

页数：6

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