Stem Cell Transplantation for Chronic Myeloid Leukemia (CML): Current Indications and Perspectives

被引：2

作者：

Bacigalupo, Andrea ^{[1
]}

机构：

[1] IRCCS AOU San Martino IST, Div Ematol & Trapianto Midollo Osseo, I-16132 Genoa, Italy

来源：

CURRENT CANCER DRUG TARGETS | 2013年 / 13卷 / 07期

关键词：

allogeneic stem cell transplantation; cost-effectiveness; chronic myeloid leukemia; cure; treatment-related mortality; tyrosine kinase inhibitors; KINASE INHIBITOR ERA; IMATINIB MESYLATE; ALLOGENEIC TRANSPLANTATION; IMPACT; DONOR; T315I;

D O I：

10.2174/15680096113136660094

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The introduction of tyrosine kinase inhibitors (TKIs) has reduced the indications for allogeneic stem cell transplants (SCT) in patients with chronic myeloid leukemia (CML) from 1500/year in 2000 to approximately 500/year in 2010. The recently updated indications by the European Leukemia Network include advanced-phase CML and non-responders to second-line TKIs. Changes in transplant programs, over the past decade, have resulted in a significant reduction in transplant related mortality and this has expanded the transplant option to older patients, who may be eligible for SCT. Transplantation for blastic phase CML remains a challenge due to the high rate of post-transplant relapses. Thus, in view of this issue, several studies of TKIs after allogeneic SCT have been undertaken with encouraging results. In conclusion, allogeneic SCT remains a therapeutic option for selected patients with CML and is currently being integrated with the use of TKIs both before and after transplantation.

引用

页码：775 / 778

页数：4

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